Quantification of the filtering bleb's structure with anterior segment optical coherence tomography.
Kokubun Taiki, Kunikata Hiroshi, Tsuda Satoru, Himori Noriko, Maruyama Kazuichi, Nakazawa Toru
AI Summary
AS-OCT bleb structure, particularly early horizontal brightness, correlates with post-trabeculectomy IOP. This offers a potential tool to predict surgical success.
Abstract
Background
The aim of the study is to determine the relationship between post-trabeculectomy bleb structure evaluated using anterior segment optical coherence tomography (AS-OCT) and postoperative intraocular pressure (IOP).
Design
Rretrospective is showed for the design of this study.
Participants
There are twenty-seven eyes of 27 trabeculectomy patients.
Methods
We drew contour lines for the bleb and cleft on 8-radius-scanned AS-OCT images, and determined correlations of AS-OCT measurements to postoperative IOP at 6 months.
Main outcome measures
The parameter used in this study is an anterior segment optical coherence tomography measurements of bleb structure, including cleft volume, wall volume, and the brightness of the bleb wall.
Results
We found significant correlations between postoperative IOP at 6 months and cleft volume at 3 and 6 months (r = -0.56, P = 0.007 and r = -0.82, P <0.001), bleb wall volume at 6 months (r = -0.48, P = 0.042), bleb vertical brightness at 3 and 6 months (r = 0.73, P < 0.001 and r = 0.49, P = 0.040), and bleb horizontal brightness at 1 week, 2 weeks, 3 months and 6 months (r = 0.49, P = 0.016, r = 0.65, P < 0.001, r = 0.52, P = 0.013 and r = 0.71, P = 0.001). A stepwise multiple regression analysis of bleb structural measurements made ≤2 weeks postoperatively showed that the strongest independent factor indicating postoperative IOP at 6 months was bleb horizontal brightness at 2 weeks (β = 0.50, P = 0.006).
Conclusions
Early postoperative AS-OCT measurements of blebs, especially horizontal brightness of the bleb wall, were associated with postoperative IOP at 6 months. AS-OCT measurements of blebs may be useful predictors of trabeculectomy outcomes.
MeSH Terms
Shields Classification
Key Concepts5
In a retrospective study of 27 eyes from 27 trabeculectomy patients, postoperative intraocular pressure (IOP) at 6 months was significantly correlated with cleft volume at 3 months (r = -0.56, P = 0.007) and 6 months (r = -0.82, P < 0.001), as measured by anterior segment optical coherence tomography (AS-OCT).
In a retrospective study of 27 eyes from 27 trabeculectomy patients, postoperative intraocular pressure (IOP) at 6 months was significantly correlated with bleb wall volume at 6 months (r = -0.48, P = 0.042), as measured by anterior segment optical coherence tomography (AS-OCT).
In a retrospective study of 27 eyes from 27 trabeculectomy patients, postoperative intraocular pressure (IOP) at 6 months was significantly correlated with bleb vertical brightness at 3 months (r = 0.73, P < 0.001) and 6 months (r = 0.49, P = 0.040), as measured by anterior segment optical coherence tomography (AS-OCT).
In a retrospective study of 27 eyes from 27 trabeculectomy patients, postoperative intraocular pressure (IOP) at 6 months was significantly correlated with bleb horizontal brightness at 1 week (r = 0.49, P = 0.016), 2 weeks (r = 0.65, P < 0.001), 3 months (r = 0.52, P = 0.013), and 6 months (r = 0.71, P = 0.001), as measured by anterior segment optical coherence tomography (AS-OCT).
In a retrospective study of 27 eyes from 27 trabeculectomy patients, a stepwise multiple regression analysis of bleb structural measurements made ≤2 weeks postoperatively showed that bleb horizontal brightness at 2 weeks was the strongest independent factor indicating postoperative intraocular pressure (IOP) at 6 months (β = 0.50, P = 0.006).
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