The association between systemic oxidative stress and ocular blood flow in patients with normal-tension glaucoma.
Himori Noriko, Kunikata Hiroshi, Shiga Yukihiro, Omodaka Kazuko, Maruyama Kazuichi, Takahashi Hidetoshi, Nakazawa Toru
AI Summary
This study found that systemic oxidative stress biomarkers correlate with reduced ocular blood flow and disease severity in normal-tension glaucoma, suggesting oxidative stress contributes to NTG pathogenesis.
Abstract
Purpose
To evaluate the association between ocular blood flow and biomarkers of systemic oxidative stress, as well as the potential of these biomarkers to assess normal-tension glaucoma (NTG).
Methods
This study included 73 eyes of 73 patients with NTG. We assessed ocular blood flow by measuring mean blur rate (MBR) in the optic nerve head using laser speckle flowgraphy, both overall and separately in the vessel and tissue areas. We also measured urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and skin autofluorescence (SAF), and lastly, determined correlations between these measurements and with other clinical parameters.
Results
SAF was correlated with age, circumpapillary retinal nerve fiber layer thickness (cpRNFLT), mean deviation (MD), and overall MBR (P = 0.003, P = 0.013, P = 0.015 and P = 0.006, respectively). SAF and 8-OHdG were both correlated with tissue-area MBR (P = 0.006 and P = 0.010, respectively). Visual acuity, cpRNFLT, mean deviation and tissue-area MBR had a significant tendency to change with NTG severity (P = 0.014, P < 0.001, P < 0.001 and P = 0.006, respectively). Multiple regression analysis revealed that cpRNFLT and 8-OHdG were independent contributing factors to MD (P < 0.001 and P = 0.040, respectively), and that cpRNFLT and 8-OHdG were independent contributing factors to tissue-area MBR (P = 0.005 and P = 0.028, respectively).
Conclusions
We found a close relationship between cpRNFLT, MD, tissue MBR, SAF and 8-OHdG, suggesting that systemic oxidative stress is associated with decreased ocular blood flow and may be involved in the pathogenesis of NTG.
MeSH Terms
Shields Classification
Key Concepts5
In a cross-sectional study of 73 eyes of 73 patients with normal-tension glaucoma (NTG), skin autofluorescence (SAF) was correlated with age (P = 0.003), circumpapillary retinal nerve fiber layer thickness (cpRNFLT) (P = 0.013), mean deviation (MD) (P = 0.015), and overall mean blur rate (MBR) (P = 0.006).
In a cross-sectional study of 73 eyes of 73 patients with normal-tension glaucoma (NTG), skin autofluorescence (SAF) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) were both correlated with tissue-area mean blur rate (MBR) (P = 0.006 and P = 0.010, respectively).
In a cross-sectional study of 73 eyes of 73 patients with normal-tension glaucoma (NTG), visual acuity, circumpapillary retinal nerve fiber layer thickness (cpRNFLT), mean deviation (MD), and tissue-area mean blur rate (MBR) had a significant tendency to change with NTG severity (P = 0.014, P < 0.001, P < 0.001, and P = 0.006, respectively).
In a cross-sectional study of 73 eyes of 73 patients with normal-tension glaucoma (NTG), multiple regression analysis revealed that circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) were independent contributing factors to mean deviation (MD) (P < 0.001 and P = 0.040, respectively).
In a cross-sectional study of 73 eyes of 73 patients with normal-tension glaucoma (NTG), multiple regression analysis revealed that circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) were independent contributing factors to tissue-area mean blur rate (MBR) (P = 0.005 and P = 0.028, respectively).
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