Peripapillary Atrophy Area as an Indicator of Glaucomatous Structural and Functional Progression.
Khreish Maroun, Schuman Joel S, Lee TingFang, Ghassabi Zeinab, Zambrano Ronald, Hu Jiyuan, Ishikawa Hiroshi, Wollstein Gadi, Lavinsky Fabio
AI Summary
OCT-measured peripapillary atrophy area changes indicate glaucoma progression in structure (GCIPL) and function (visual field), offering a new monitoring tool.
Abstract
Purpose
To determine whether peripapillary atrophy (PPA) area is an indicator of glaucomatous structural and functional damage and progression.
Methods
In this retrospective longitudinal analysis from ongoing prospective study we qualified 71 eyes (50 subjects) with glaucoma. All subjects had a comprehensive ophthalmic examination, visual field (VF), and spectral-domain optical coherence tomography (OCT) testing in at least three visits. PPA was manually delineated on en face OCT optic nerve head scans, while observing the corresponding cross-sectional images, as the hyper-reflective area contiguous with the optic disc.
Results
The mean follow-up duration was 4.4 ± 1.4 years with an average of 6.8 ± 2.2 visits. At baseline, PPA area was significantly associated only with VF's mean deviation (MD; P = 0.041), visual field index (VFI; P = 0.041), superior ganglion cell inner plexiform layer (GCIPL; P = 0.011), and disc area (P = 0.011). Longitudinally, PPA area was negatively and significantly associated with MD (P = 0.015), VFI (P = 0.035), GCIPL (P = 0.009), superior GCIPL (P = 0.034), and disc area (P = 0.007, positive association).
Conclusions
Longitudinal change in PPA area is an indicator of glaucomatous structural and functional progression but PPA area at baseline cannot predict future progression.
Translational relevance: Longitudinal changes in peripapillary atrophy area measured by OCT can be an indicator of structural and functional glaucoma progression.
MeSH Terms
Shields Classification
Key Concepts5
A retrospective longitudinal analysis of 71 eyes (50 subjects) with glaucoma, with a mean follow-up of 4.4 ± 1.4 years, found that longitudinally, peripapillary atrophy (PPA) area was negatively and significantly associated with mean deviation (MD; P = 0.015), visual field index (VFI; P = 0.035), and ganglion cell inner plexiform layer (GCIPL; P = 0.009).
A retrospective longitudinal analysis of 71 eyes (50 subjects) with glaucoma, with a mean follow-up of 4.4 ± 1.4 years, found that longitudinally, peripapillary atrophy (PPA) area was negatively and significantly associated with superior ganglion cell inner plexiform layer (GCIPL; P = 0.034) and positively associated with disc area (P = 0.007).
A retrospective longitudinal analysis of 71 eyes (50 subjects) with glaucoma concluded that longitudinal change in peripapillary atrophy (PPA) area is an indicator of glaucomatous structural and functional progression.
A retrospective longitudinal analysis of 71 eyes (50 subjects) with glaucoma concluded that peripapillary atrophy (PPA) area at baseline cannot predict future progression.
A retrospective longitudinal analysis of 71 eyes (50 subjects) with glaucoma found that at baseline, peripapillary atrophy (PPA) area was significantly associated with visual field's mean deviation (MD; P = 0.041), visual field index (VFI; P = 0.041), superior ganglion cell inner plexiform layer (GCIPL; P = 0.011), and disc area (P = 0.011).
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