Longitudinal changes in optical coherence tomography angiography characteristics in normal-tension glaucoma with or without high myopia.
Lai Chin, Chuang Lan-Hsin, Lai Chi-Chun, Liu Chun-Fu, Yang Ju-Wen, Chen Henry S L
AI Summary
NTG eyes showed microvascular and structural loss despite stable vision. Parafovea vessel density decline correlated with visual field loss, and high myopia may accelerate this progression.
Abstract
Purpose
To evaluate the structural, microvascular, and functional progression of normal tension glaucoma (NTG) with or without high myopia by examining longitudinal changes in optical coherence tomography angiography (OCTA) and visual field (VF) parameters.
Methods
We evaluated 61 NTG eyes and classified 25 of the eyes with axial lengths (ALs) of ≥26 mm as highly myopic. We assessed the rate of change in OCTA parameters, namely radial peripapillary capillary (RPC) vessel density (VD), parafovea VD, deep parafovea VD, retinal nerve fibre layer (RNFL) thickness, and ganglion cell complex thickness. We evaluated the correlation of the rate of change in OCTA parameters with VF loss and AL.
Results
Among the 61 NTG eyes, rates of loss of RPC VD, parafovea VD, deep parafovea VD, and RNFL thickness were significantly different from zero despite the nonsignificant rate of change in VF mean deviation (MD). Changes in these OCTA parameters did not differ significantly in highly myopic NTG eyes. The rate of change in VF MD was significantly correlated with the rate of change in parafovea VD in highly myopic and non-highly myopic NTG eyes. In highly myopic NTG eyes, AL was negatively correlated with the rates of loss of RNFL thickness, VF MD, and VF PSD.
Conclusion
NTG eyes with a relatively stable VF exhibited loss of VD and RNFL thickness. VF progression in NTG was correlated with decreasing parafovea VD, indicating a structure-function correlation. Greater AL may indicate faster VF loss and RNFL thinning in highly myopic NTG eyes.
MeSH Terms
Shields Classification
Key Concepts4
In a longitudinal study of 61 normal-tension glaucoma (NTG) eyes, rates of loss of radial peripapillary capillary (RPC) vessel density (VD), parafovea VD, deep parafovea VD, and retinal nerve fibre layer (RNFL) thickness were significantly different from zero, despite a nonsignificant rate of change in visual field (VF) mean deviation (MD).
In a longitudinal study of 61 normal-tension glaucoma (NTG) eyes, changes in optical coherence tomography angiography (OCTA) parameters (radial peripapillary capillary (RPC) vessel density (VD), parafovea VD, deep parafovea VD, and retinal nerve fibre layer (RNFL) thickness) did not differ significantly in 25 highly myopic NTG eyes (axial lengths of ≥26 mm) compared to non-highly myopic NTG eyes.
In a longitudinal study of 61 normal-tension glaucoma (NTG) eyes, the rate of change in visual field (VF) mean deviation (MD) was significantly correlated with the rate of change in parafovea vessel density (VD) in both highly myopic and non-highly myopic NTG eyes.
In a longitudinal study of 25 highly myopic normal-tension glaucoma (NTG) eyes (axial lengths of ≥26 mm), axial length (AL) was negatively correlated with the rates of loss of retinal nerve fibre layer (RNFL) thickness, visual field (VF) mean deviation (MD), and VF pattern standard deviation (PSD).
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