SYSTEMATIC REVIEW AND META-ANALYSIS OF OPTICAL COHERENCE TOMOGRAPHY MEASUREMENTS IN PATIENTS WITH CHRONIC KIDNEY DISEASE.

Purpose

To assess neurodegeneration and chorioretinal thickness in subjects with and without chronic kidney disease (CKD).

Methods

PubMed, Web of Science, Scopus, and Embase were searched using proper keywords for articles published in the English language from their inception until January 2024. Publications were included if they reported optical coherence tomography measurements of retinal or choroidal layers in patients with CKD compared with healthy or non-CKD controls. We used a random-effects model to calculate pooled standardized mean difference (SMD) estimates and 95% confidence intervals (CIs).

Results

Twelve studies, with 29,340 patients, were included in quantitative synthesis. In comparison to controls, patients with CKD had a significantly lower value for average retinal thickness (SMD [CI], -0.35 [-0.58 to -0.12], P = 0.028), choroidal thickness (SMD [CI], -1.84 [-4.17 to 0.49], P = 0.122), macular ganglion cell-inner plexiform layer (SMD [CI], -0.58 [-0.78 to -0.38]], P < 0.001), and peripapillary retinal nerve fiber layer thickness (SMD [CI], -0.32 [-0.44 to -0.20], P < 0.001). Significant retinal nerve fiber layer thinning was observed in both diabetic CKD excluded and not excluded subgroups.

Conclusion

Compared with controls, the eyes of patients with CKD have significantly thinner retina, ganglion cell-inner plexiform layer, and retinal nerve fiber layer.