Comparison of baseline clinical characteristics and patterns of visual field defects between high-tension and normal-tension glaucoma.
Chen Zidong, Yang Wenxin, Yang Yangfan, Jiang Yuzhen, Zhang Yuning, Zhang Xinyi, Luo Chongxuan, Wang Mingqin, Fan Yanmei, Liu Pingping
AI Summary
This study found normal-tension glaucoma patients were older, female, and showed more visual field asymmetry than high-tension glaucoma, potentially worsened by IOP fluctuations.
Abstract
Aims
To compare the baseline clinical characteristics and patterns of visual field defects between high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) in the Laser in Glaucoma and Ocular Hypertension (LiGHT) China subjects.
Methods
All patients (n=622) were recruited at Zhongshan Ophthalmic Center from 2015 to 2019. 1105 open-angle glaucoma eyes of 622 patients were classified as NTG (n=559) and HTG eyes (n=546) according to the baseline intraocular pressure (IOP) of 21 mm Hg. The mean deviation (MD), regional MD of the Glaucoma Hemifield Test regions and regional difference values were calculated. Daytime phasing IOP was recorded at 8:00, 10:00, 11:30, 14:30 and 17:00 hour. Multiple regression analyses were conducted for each regional difference.
Results
Patients with NTG were older, more likely to be female, hypertensive and suffer ischaemic heart disease than patients with HTG (p<0.05 for all comparisons). HTG showed higher mean daytime phasing IOP and higher daytime fluctuations than NTG (p<0.001 for all comparisons). HTG and NTG showed similar MD overall (p=0.665). NTG showed significantly greater hemifield asymmetry than HTG. The two arcuate regional differences in NTG were significantly associated with daytime IOP fluctuations (p<0.01 in both regions).
Conclusions
In the LiGHT China trial, NTG and HTG showed similar visual field defects severity at enrolment. However, NTG showed more severe hemifield asymmetry compared with HTG, and higher short-time IOP fluctuations might exacerbate this asymmetry in NTG.
MeSH Terms
Shields Classification
Key Concepts5
Patients with normal-tension glaucoma (NTG) in the LiGHT China study were older, more likely to be female, hypertensive, and suffer from ischaemic heart disease than patients with high-tension glaucoma (HTG) (p<0.05 for all comparisons).
High-tension glaucoma (HTG) showed higher mean daytime phasing intraocular pressure (IOP) and higher daytime IOP fluctuations than normal-tension glaucoma (NTG) (p<0.001 for all comparisons) in the LiGHT China study.
Normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) showed similar mean deviation (MD) overall (p=0.665) at enrolment in the LiGHT China trial.
Normal-tension glaucoma (NTG) showed significantly greater hemifield asymmetry compared with high-tension glaucoma (HTG) in the LiGHT China trial.
In normal-tension glaucoma (NTG) patients in the LiGHT China trial, the two arcuate regional differences were significantly associated with daytime intraocular pressure (IOP) fluctuations (p<0.01 in both regions).
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