Assessment of the corneal biomechanical features of granular corneal dystrophy type 2 using dynamic ultra-high-speed Scheimpflug imaging.
Tanikawa Akira, Soma Takeshi, Miki Atsuya, Koh Shizuka, Kitaguchi Yoshiyuki, Maeda Naoyuki, Oie Yoshinori, Kawasaki Satoshi, Nishida Kohji
AI Summary
GCD2 eyes have softer corneas, with a biomechanical index correlating to lesion deposition. This suggests potential IOP underestimation, requiring careful glaucoma management.
Abstract
Purpose
To evaluate the corneal biomechanical features of eyes with granular corneal dystrophy type 2 (GCD2) by analyzing corneal biomechanical indices obtained using a Corvis ST (CST) dynamic ultra-high-speed Scheimpflug imaging device.
Methods
In this retrospective case-control study, 35 CST parameters were compared in normal eyes (control) and eyes of patients with GCD2 treated at Osaka University Hospital, Osaka, Japan. The parameters included the Corvis Biomechanical Index (CBI), which is important in differentiating eyes with keratoconus from normal eyes. We measured the deposition rates of lesions in the central 7-mm region of the eye and assessed the correlation between the deposition rate and the CBI.
Results
Twenty-one eyes with GCD2 and 23 control eyes were analyzed. Eyes with GCD2 showed significantly less corneal stiffness in 15 CST parameters than did control eyes. In particular, the CBI was remarkably higher in eyes with GCD2 than in control eyes (P = 0.000006). Additionally, the deposition rate and the CBI were positively correlated.
Conclusions
GCD2 eyes had softer corneas than did control eyes in most biomechanical CST parameters, and one of the parameters (the CBI) was linked to the rate of deposited lesions. Since IOP may be underestimated in GCD2 eyes, management should be especially careful in GCD2 cases complicated by glaucoma.
MeSH Terms
Shields Classification
Key Concepts4
In a retrospective case-control study, eyes with granular corneal dystrophy type 2 (GCD2) showed significantly less corneal stiffness in 15 Corvis ST (CST) parameters than did 23 control eyes.
In a retrospective case-control study, the Corvis Biomechanical Index (CBI) was remarkably higher in 21 eyes with granular corneal dystrophy type 2 (GCD2) than in 23 control eyes (P = 0.000006).
In a retrospective case-control study, the deposition rate of lesions in the central 7-mm region of the eye and the Corvis Biomechanical Index (CBI) were positively correlated in eyes with granular corneal dystrophy type 2 (GCD2).
Management of intraocular pressure (IOP) should be especially careful in granular corneal dystrophy type 2 (GCD2) cases complicated by glaucoma, as IOP may be underestimated in GCD2 eyes due to softer corneas.
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