Intrasession Repeatability of OCT Angiography Parameters in Neurodegenerative Disease.
Akrobetu Dennis Y, Robbins Cason B, Ma Justin P, Soundararajan Srinath, Quist Michael S, Stinnett Sandra S, Moore Kathryn P L, Johnson Kim G, Liu Andy J, Grewal Dilraj S
AI Summary
This study found macular OCTA parameters show moderate to good intrasession repeatability, similarly across neurodegenerative diseases and healthy controls, indicating reliable measurements for clinical use.
Abstract
Purpose
To assess the intrasession repeatability of macular OCT angiography (OCTA) parameters in Alzheimer's disease (AD), mild cognitive impairment (MCI), Parkinson's disease (PD), and normal cognition (NC).
Design
Cross sectional study.
Subjects
Patients with a clinical diagnosis of AD, PD, MCI, or NC were imaged. Images with poor quality and of those with diabetes mellitus, glaucoma, or vitreoretinal disease were excluded from analysis.
Methods intervention or testing: All participants were imaged using the Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Software Version 11.0.0.29946) and repeat OCTA images were obtained for both eyes. Perfusion density (PFD), vessel density (VD), and Foveal avascular zone (FAZ) area were measured from 3 × 3 mm and 6 × 6 mm OCTA images centered on the fovea using an ETDRS grid overlay.
Main outcome measures
Intraclass correlation coefficients were used to quantify repeatability of PFD, VD, and FAZ area measurements obtained from imaging.
Results
3 × 3 mm scans of 22 AD, 40 MCI, 21 PD, and 26 NC participants and 6 × 6 mm scans of 29 AD, 44 MCI, 29 PD, and 30 NC participants were analyzed. Repeatability values ranged from 0.64 (0.49-0.82) for 6 × 6 mm PFD in AD participants to 0.87 (0.67-0.92) for 3 × 3 mm PFD in AD participants. No significant differences were observed in repeatability between NC participants and those with neurodegenerative disease.
Conclusions
Overall, similar OCTA repeatability was observed between NC participants and those with neurodegeneration. Regardless of diagnostic group, macular OCTA metrics demonstrated moderate to good repeatability.
Financial disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article.
Shields Classification
Key Concepts4
Repeatability values for macular OCT angiography (OCTA) parameters ranged from 0.64 (0.49-0.82) for 6 6 mm perfusion density (PFD) in Alzheimer's disease (AD) participants to 0.87 (0.67-0.92) for 3 3 mm PFD in AD participants.
No significant differences were observed in macular OCT angiography (OCTA) repeatability between normal cognition (NC) participants and those with neurodegenerative disease (Alzheimer's disease, mild cognitive impairment, Parkinson's disease).
Macular OCT angiography (OCTA) metrics demonstrated moderate to good repeatability regardless of diagnostic group (Alzheimer's disease, mild cognitive impairment, Parkinson's disease, or normal cognition).
Intrasession repeatability of macular OCT angiography (OCTA) parameters was assessed in patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), Parkinson's disease (PD), and normal cognition (NC).
Related Articles5
Prosthetic Visual Acuity with the PRIMA Subretinal Microchip in Patients with Atrophic Age-Related Macular Degeneration at 4 Years Follow-up.
Clinical TrialLong-term Follow-up of a Phase 1/2a Clinical Trial of a Stem Cell-Derived Bioengineered Retinal Pigment Epithelium Implant for Geographic Atrophy.
Clinical TrialDetecting retinal cell stress and apoptosis with DARC: Progression from lab to clinic.
ReviewChoroidal blood flow response to isometric exercise in glaucoma patients and patients with ocular hypertension.
Observational StudyAbility and reproducibility of Fourier-domain optical coherence tomography to detect retinal nerve fiber layer atrophy in Parkinson's disease.
Cross-Sectional StudyIs this article assigned to the wrong chapter(s)? Let us know.