Optical coherence tomography homography for detection of retinal displacement: a validation study.
Brosh Koby, Roditi Eduardo, Bansal Aditya, Martins Melo Isabela, Potter Michael J, Muni Rajeev H
AI Summary
This study validated an OCT homography technique, finding it highly sensitive and specific for detecting retinal displacement. This reliable method could improve monitoring of post-RRD repair outcomes.
Abstract
Purpose
Retinal displacement following rhegmatogenous retinal detachment (RRD) has been associated with inferior functional outcomes. Recent evidence using an overlay technique suggests that fundus-autofluorescence underestimates post-RRD repair retinal displacement. This study aims to validate the overlay technique in normal eyes and to determine its sensitivity and specificity at detecting retinal displacement.
Methods
We conducted a retrospective case series involving 66 normal eyes, each with at least two separate infrared (IR) images at different time points. Overlay of the two images was based on manual marking of choroidal and optic nerve head (ONH) landmarks. For each set of two IR images, computer code for homography generated two outputs, flipping view video and an overlay picture. First, validation of choroidal/ONH alignment was performed using the flipping view video to ensure accurate manual markings. Then, two different masked graders (AB + IM) evaluated the overlays for presence of retinal displacement. 16 control eyes following RRD repair with detected retinal displacement on FAF imaging assessed sensitivity and specificity of the technique.
Results
94% of overlays were found to be well aligned (62/66). 11 cases exhibited errors on flipping view analysis (choroidal/ONH misalignment). Those 11 cases had a significantly higher rate of retinal displacement (false positives) compared to cases without errors (8/11,72% Vs 54/55,98%,P = 0.001). Sensitivity and specificity of the overlay technique for detecting retinal displacement considering only adequate flipping view cases (n = 55) were calculated as 100% and 98%, respectively.
Conclusions
IR overlay emerges as a reliable and valid method for detecting retinal displacement, exhibiting excellent sensitivity and specificity.
MeSH Terms
Shields Classification
Key Concepts6
94% (62/66) of overlays were found to be well aligned in a retrospective case series of 66 normal eyes using infrared images and homography.
In cases with adequate flipping view (n=55), the infrared overlay technique demonstrated a sensitivity of 100% and a specificity of 98% for detecting retinal displacement, as assessed in 16 control eyes following RRD repair with detected retinal displacement on FAF imaging.
The infrared (IR) overlay technique is a reliable and valid method for detecting retinal displacement, exhibiting excellent sensitivity (100%) and specificity (98%) in a validation study.
Retinal displacement following rhegmatogenous retinal detachment (RRD) has been associated with inferior functional outcomes.
Fundus-autofluorescence (FAF) underestimates post-RRD repair retinal displacement, as suggested by recent evidence using an overlay technique.
A retrospective case series involving 66 normal eyes with at least two separate infrared (IR) images at different time points was conducted to validate the overlay technique for detecting retinal displacement.
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