Ocular hypertension and the risk of blindness.
Gestel Aukje van, Carroll A B Webers, Henny J M Beckers, Andrea Peeters, Johan L Severens, Jan S A G Schouten
Summary
The best estimates of the 15-year risk of unilateral blindness in patients with OHT, based on the currently available empirical data and an appropriate model, show that the risk is <10%.
Abstract
PURPOSE
To estimate the risk of blindness in patients with ocular hypertension (OHT) using an appropriate model and current empirical data.
DESIGN
A Markov model with data from a systematic literature review.
METHODS
A Markov model with 3 health states was built: OHT, primary open-angle glaucoma (POAG), and unilateral blindness. Literature was searched for reports on conversion from OHT to POAG and progression from POAG to blindness, to estimate a range of annual conversion and progression probabilities. The model had a cycle length of 1 year.
RESULTS
The 15-year risk estimates ranged from 3.1% to 9.4% in untreated, and from 0.9% to 8.6% in treated patients with OHT. The ranges were the result of differences in patient populations, treatments, and outcome definitions in currently available empirical data.
CONCLUSIONS
The best estimates of the 15-year risk of unilateral blindness in patients with OHT, based on the currently available empirical data and an appropriate model, show that the risk is <10%.
Top Research in Disease Progression
Browse all →Estimating Optical Coherence Tomography Structural Measurement Floors to Improve Detection of Progression in Advanced Glaucoma.
Progressive Macula Vessel Density Loss in Primary Open-Angle Glaucoma: A Longitudinal Study.
Detecting Structural Progression in Glaucoma with Optical Coherence Tomography.
In the Knowledge Library
Discussion
Comments and discussion will appear here in a future update.