Infantile glaucoma in Down's syndrome (trisomy 21).
Traboulsi E I, Levine E, Mets M B, Parelhoff E S, O'Neill J F, Gaasterland D E
AI Summary
This study found infantile glaucoma in Down's syndrome often presents early, but delayed diagnosis can occur. Coexisting glaucoma, severe myopia, and cataracts strongly increase retinal detachment risk, leading to poor vision.
Abstract
We examined five patients with Down's syndrome and bilateral infantile glaucoma. In the first few months of life four patients had large cloudy corneas, breaks in Descemet's membrane, increased intraocular pressure, photophobia, and tearing. In one patient the diagnosis was delayed until 3 1/2 years of age because of concomitant nasolacrimal duct obstruction. Two patients developed cataracts and retinal detachment and have undergone multiple surgical procedures. The clinical course in these two older patients suggests that coexistence of congenital glaucoma, severe myopia, and cataracts in patients with trisomy 21 strongly predisposes for the development of retinal detachment and poor visual outcome.
MeSH Terms
Shields Classification
Related Articles5
Congenital glaucoma associated with a chromosomal abnormality.
Case ReportCongenital unilateral buphthalmos in Walker-Warburg syndrome: a clinicopathological study.
Case SeriesAnterior segment dysgenesis in mosaic Turner syndrome.
Case SeriesBiometry in X linked megalocornea: pathognomonic findings.
Case SeriesOphthalmological abnormalities in children with congenital disorders of glycosylation type I.
Case SeriesIs this article assigned to the wrong chapter(s)? Let us know.