Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study.
Chen Jiang, Ronald B Melles, Poorab Sangani, Thomas J Hoffmann, Pirro G Hysi, M Maria Glymour, Eric Jorgenson, Salil A Lachke, Hélène Choquet
Summary
Our results provide evidence that genetic risks for POAG and myopia may be causal risk factors for age-related cataract.
Abstract
PURPOSE
To investigate the association of genetically determined primary open-angle glaucoma (POAG), myopic refractive error (RE), type 2 diabetes (T2D), blood pressure (BP), body mass index (BMI), cigarette smoking, and alcohol consumption with the risk of age-related cataract.
METHODS
To assess potential causal effects of clinical or behavioral factors on cataract risk, we conducted two-sample Mendelian randomization analyses. Genetic instruments, based on common genetic variants associated with risk factors at genome-wide significance (P 0.05).
CONCLUSIONS
Our results provide evidence that genetic risks for POAG and myopia may be causal risk factors for age-related cataract. These results are consistent with previous observational studies reporting associations of myopia with cataract risk. This information may support population cataract risk stratification and screening strategies.
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