Hysi Pirro G

Comparison of Associations with Different Macular Inner Retinal Thickness Parameters in a Large Cohort: The UK Biobank.

The novel associations we identified may be important to consider when using inner retinal parameters as a diagnostic tool.

Association Between Myopic Refractive Error and Primary Open-Angle Glaucoma: A 2-Sample Mendelian Randomization Study.

These findings demonstrate a shared genetic basis and an association between myopic RE and POAG risk. This may support population POAG risk stratification and screening strategies, based on RE information.

Alcohol, Intraocular Pressure, and Open-Angle Glaucoma: A Systematic Review and Meta-analysis.

Although this meta-analysis suggests a harmful association between alcohol use and OAG, our results should be interpreted cautiously given the weakness and heterogeneity of the underlying evidence base, the small absolute effect size, and the borderline statistical significance.

Evaluation of the Myocilin Mutation Gln368Stop Demonstrates Reduced Penetrance for Glaucoma in European Populations.

The significance of this finding is that higher numbers of healthy individuals in the population are expected to be carriers of this mutation, which in turn reduces the utility of identifying carriers of this mutation…

Genetic Heritability of Pigmentary Glaucoma and Associations With Other Eye Phenotypes.

These findings support the conclusion that pigmentary glaucoma may have a genetic basis and be highly heritable.

Association of Behavioral and Clinical Risk Factors With Cataract: A Two-Sample Mendelian Randomization Study.

Our results provide evidence that genetic risks for POAG and myopia may be causal risk factors for age-related cataract.

Genetic Correlations Between Diabetes and Glaucoma: An Analysis of Continuous and Dichotomous Phenotypes.

These analyses suggest that there is limited genetic correlation between diabetes- and glaucoma-related traits.

Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development.

Common SNPs relating to the GSAP and GRM5/TYR genes are associated risk factors for the development of PDS and PG.

Smoking, Corneal Biomechanics, and Glaucoma: Results From Two Large Population-Based Cohorts.

Cigarette smoking seems to increase corneal biomechanical resistance to deformation, but there was little evidence to support a relationship with glaucoma.

Genetic Associations Between Smoking- and Glaucoma-Related Traits.

MR experiments and GRS generated from Rotterdam Study participants support an inverse relationship between smoking and glaucoma.

The Role of Chromosome X in Intraocular Pressure Variation and Sex-Specific Effects.

In this study, we report the results of genomewide levels of association of three loci on chromosome X with IOP, and provide a framework to include chromosome X in large-scale genomewide association analyses for complex…

Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort.

This study finds for the first time, to our knowledge, that medication use is associated with refractive error in adults.

An Ocular Gene-Set Expression Library for Heritability Partition and Cell Line Enrichment Analyses.

We have built a structured ocular transcriptomics library to estimate cell line enrichment among association signals from genome-wide association studies that may be extended by incorporating other datasets.