Low levels of pigment epithelium-derived factor in highly myopic eyes with chorioretinal atrophy.
Ogata Nahoko, Imaizumi Masahito, Miyashiro Miki, Arichi Miwa, Matsuoka Masato, Ando Akira, Matsumura Miyo
AI Summary
Highly myopic eyes, especially with chorioretinal atrophy, showed significantly lower aqueous PEDF levels. This suggests PEDF reduction may contribute to myopic degeneration, potentially guiding future therapeutic strategies.
Abstract
Purpose
To determine the concentration of pigment epithelium-derived factor (PEDF) in the aqueous humor of highly myopic eyes.
Design
Observational case series.
Methods
The PEDF concentration in the aqueous humor of 23 eyes of 17 patients with high myopia (axial length >26 mm) who underwent cataract surgery was measured by enzyme-linked immunosorbent assay.
Results
The mean concentration of PEDF in eyes with high myopia (0.54 +/- 0.12 microg/ml) was significantly lower than that in control eyes (0.86 +/- 0.04 microg/ml, P = .0022). The PEDF level in myopic eyes with chorioretinal atrophy (0.32 +/- 0.05 microg/ml) was lower than that in myopic eyes without chorioretinal atrophy (0.71 +/- 0.12 microg/ml; P = .041) and control eyes (P = .0003).
Conclusions
The significantly lower concentration of PEDF in eyes with chorioretinal atrophy-associated high myopia probably resulted from degeneration of the retinal pigment epithelial cells and/or the retinal ganglion cells that are the main sources of PEDF in the eye.
MeSH Terms
Shields Classification
Related Articles5
Neuronal Degeneration and Glial Activation in the Absence of Vascular Changes in Human Retinas of Patients With Diabetes.
Basic ScienceRabies: ocular pathology.
Case ReportProtein C and protein S deficiency associated with retinal, optic nerve, and cerebral ischaemia.
Case ReportDeath of retinal neurons in streptozotocin-induced diabetic mice.
Basic ScienceImmunopathologic features of retinal lesions in multiple sclerosis.
Basic ScienceIs this article assigned to the wrong chapter(s)? Let us know.