The Relationship Between Helicobacter pylori Infection and Open-Angle Glaucoma: A Meta-Analysis.
Zeng Jun, Liu Hanhan, Liu Xiao, Ding Chun
AI Summary
This meta-analysis found a significant link between *H. pylori* infection and open-angle glaucoma (OAG), particularly primary OAG and normal tension glaucoma. This suggests a potential systemic factor in OAG development.
Abstract
Purpose
Previous studies assessed the associations between Helicobacter pylori infection and open-angle glaucoma (OAG) and produced inconsistent results. Therefore, we performed a meta-analysis to evaluate the effects of H. pylori infection on OAG risk.
Methods
Relevant studies that reported the associations between H. pylori infection and OAG were identified through an extensive search of the Exerpta Medica Database (EMBASE), Web of Science, and PubMed databases in English and Chinese National Knowledge Infrastructure, VIP, and Wan Fang databases in Chinese, and by reviewing the reference lists of the key articles. The summary odds ratio (OR) and 95% confidence interval (CI) were calculated using the random-effects model.
Results
This meta-analysis involved 695 glaucoma patients and 1580 control individuals. The overall combined ORs showed a significant correlation between H. pylori infection and OAG (OR = 2.08, 95% CI = 1.42-3.04). The subgroup analysis showed the association of H. pylori infection with primary open-angle glaucoma (POAG; OR = 3.06, 95% CI = 1.27-2.46) and normal tension glaucoma (NTG; OR = 1.77, 95% CI = 1.76-5.34), but not with pseudoexfoliation glaucoma (PXFG; OR = 1.46, 95% CI = 0.40-5.30).
Conclusions
The result of this meta-analysis suggested a statistically significant association between H. pylori infection and OAG. Further analysis showed that this positive relation is observed only in POAG and NTG patients, but not in the PXFG patients.
MeSH Terms
Shields Classification
Key Concepts4
A meta-analysis of studies involving 695 glaucoma patients and 1580 control individuals found a statistically significant correlation between Helicobacter pylori infection and open-angle glaucoma (OAG) with an odds ratio (OR) of 2.08 (95% CI = 1.42-3.04).
Subgroup analysis within a meta-analysis of studies involving 695 glaucoma patients and 1580 control individuals showed an association of Helicobacter pylori infection with primary open-angle glaucoma (POAG) with an OR of 3.06 (95% CI = 1.27-2.46).
Subgroup analysis within a meta-analysis of studies involving 695 glaucoma patients and 1580 control individuals showed an association of Helicobacter pylori infection with normal tension glaucoma (NTG) with an OR of 1.77 (95% CI = 1.76-5.34).
Subgroup analysis within a meta-analysis of studies involving 695 glaucoma patients and 1580 control individuals showed no statistically significant association of Helicobacter pylori infection with pseudoexfoliation glaucoma (PXFG) with an OR of 1.46 (95% CI = 0.40-5.30).
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