GANGLION CELL LAYER THICKNESS AND VISUAL IMPROVEMENT AFTER EPIRETINAL MEMBRANE SURGERY.
Song Su Jeong, Lee Mi Yeon, Smiddy William E
AI Summary
Preoperative inner retinal layer changes, specifically a higher central foveal thickness/ganglion cell layer ratio, predict better visual improvement after epiretinal membrane surgery, offering a new prognostic indicator.
Abstract
Purpose
To evaluate the possible prognostic value of preoperative individual retinal layer thicknesses measured by an automated algorithm from spectral domain optical coherence tomography and visual acuity or improvement after epiretinal membrane surgery.
Methods
Data from 76 eyes with idiopathic epiretinal membrane that underwent pars plana vitrectomy for idiopathic epiretinal membrane removal were analyzed. The preoperative thicknesses of the ganglion cell layer, inner plexiform layer, and other layers were measured using the Iowa Reference Algorithm. Each retinal layer thickness and its ratio of the central foveal thickness were compared between eyes with (Group 1) or without (Group 2) 2 or more Snellen lines of visual improvement at 3, 6, and 12 months after surgery.
Results
Higher mean central foveal thickness/ganglion cell layer ratio and symptom duration of ≤1 year were significantly more common in Group 1 (P = 0.03 and 0.04, respectively). After adjusting for age and symptom duration, lens status, and preoperative visual acuity, higher central foveal thickness/ganglion cell layer ratio was associated with ≥2 lines of visual improvement after surgery (odds ratio: 6.57, 95% confidence interval: 1.29-33.40).
Conclusion
The preoperative inner retinal layer changes may have a role independent of outer retinal layer parameters in the visual prognosis after epiretinal membrane peeling.
MeSH Terms
Shields Classification
Key Concepts5
A higher mean central foveal thickness/ganglion cell layer ratio was significantly more common in eyes with 2 or more Snellen lines of visual improvement at 3, 6, and 12 months after epiretinal membrane surgery (P = 0.03).
A symptom duration of ≤1 year was significantly more common in eyes with 2 or more Snellen lines of visual improvement at 3, 6, and 12 months after epiretinal membrane surgery (P = 0.04).
After adjusting for age, symptom duration, lens status, and preoperative visual acuity, a higher central foveal thickness/ganglion cell layer ratio was associated with ≥2 lines of visual improvement after epiretinal membrane surgery (odds ratio: 6.57, 95% confidence interval: 1.29-33.40).
Preoperative individual retinal layer thicknesses, including the ganglion cell layer and inner plexiform layer, were measured using the Iowa Reference Algorithm from spectral domain optical coherence tomography in 76 eyes with idiopathic epiretinal membrane.
The study evaluated the possible prognostic value of preoperative individual retinal layer thicknesses, measured by an automated algorithm from spectral domain optical coherence tomography, for visual acuity or improvement after epiretinal membrane surgery.
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