Relationship Between Optic Nerve Head Drusen Volume and Structural and Functional Optic Nerve Damage.
Skaat Alon, Muylaert Stephanie, Mogil Rachel S, Furlanetto Rafael L, Netto Camila F, Banik Rudrani, Liebmann Jeffrey M, Ritch Robert, Park Sung Chul
AI Summary
This study found larger optic nerve head drusen volume correlates with more structural and functional damage, highlighting drusen volume as a potential indicator of disease severity.
Abstract
Purpose
The purpose of this study is to assess the relationships between optic nerve head drusen (ONHD) volume, retinal nerve fiber layer (RNFL) thickness and visual field (VF) loss.
Methods
Patients with ONHD and no other ocular or systemic conditions that can affect RNFL or VF were enrolled. Serial enhanced depth imaging (EDI) optical coherence tomography (OCT) B-scans of the optic nerve head (interval between scans, ~30 μm) were obtained from each participant. ONHD volume was calculated for each eye by delineating the ONHD masses in each OCT B-scan using 3-dimensional reconstruction software.
Results
A total of 47 eyes (28 patients) with ONHD were included (mean age, 57±16 y). ONHD volume varied considerably [0.265±0.227 (range, 0.005 to 0.855)] mm. Linear and quadratic regression analyses demonstrated that ONHD volume is significantly associated with both global average RNFL thickness (linear R=0.531, quadratic R=0.557; P<0.001) and VF mean deviation (linear R=0.519, quadratic R=0.522; P<0.001). ONHD were most prevalent in the nasal quadrant (46 eyes, 98%), followed by superior, inferior and temporal quadrants [35 (74%), 30 (64%), and 16 (34%) eyes respectively]. The proportion of eyes with OCT RNFL defects (81%; 38/47 eyes) was significantly greater than that with VF defects (60%; 28/47 eyes) (P<0.001). RNFL defects were detected in 10 of the 19 eyes with no VF defects. RNFL defects were detected in all 28 eyes with VF defects.
Conclusions
ONHD volume generally correlates with structural and functional optic nerve damage.
MeSH Terms
Shields Classification
Key Concepts5
In a cross-sectional study of 47 eyes (28 patients) with optic nerve head drusen (ONHD), linear and quadratic regression analyses demonstrated that ONHD volume is significantly associated with both global average retinal nerve fiber layer (RNFL) thickness (linear R=0.531, quadratic R=0.557; P<0.001) and visual field (VF) mean deviation (linear R=0.519, quadratic R=0.522; P<0.001).
In a cross-sectional study of 47 eyes (28 patients) with optic nerve head drusen (ONHD), the proportion of eyes with OCT retinal nerve fiber layer (RNFL) defects (81%; 38/47 eyes) was significantly greater than that with visual field (VF) defects (60%; 28/47 eyes) (P<0.001).
In a cross-sectional study of 47 eyes (28 patients) with optic nerve head drusen (ONHD), retinal nerve fiber layer (RNFL) defects were detected in 10 of the 19 eyes with no visual field (VF) defects.
In a cross-sectional study of 47 eyes (28 patients) with optic nerve head drusen (ONHD), ONHD volume varied considerably, with a mean of 0.265±0.227 mm³ and a range of 0.005 to 0.855 mm³.
In a cross-sectional study of 47 eyes (28 patients) with optic nerve head drusen (ONHD), ONHD were most prevalent in the nasal quadrant (46 eyes, 98%), followed by superior (35 eyes, 74%), inferior (30 eyes, 64%), and temporal quadrants (16 eyes, 34%).
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