Is the Optic Nerve Head Structure Impacted by a Diagnostic Lumbar Puncture in Humans?
Poli Muriel, Denis Philippe, Sellem Eric, Aho-Glélé Ludwig-Serge, Bron Alain M
AI Summary
This study found diagnostic lumbar puncture caused no optic nerve head structural changes in healthy eyes, suggesting it's safe for deep ONH structures in non-glaucoma patients.
Abstract
Purpose
The purpose of this study is to assess in vivo whether diagnostic lumbar puncture (LP) is followed by optic nerve head (ONH) and parapapillary anatomic changes in normal human eyes.
Materials and methods
Prospective, single-center, observational case series. ONH structures (prelaminar tissue surface, anterior surface of the lamina cribrosa, central retinal vessels) and parapapillary structures (internal limiting membrane, posterior surfaces of retinal nerve fiber layer and Bruch membrane/retinal pigment epithelium complex, Bruch membrane opening, posterior surface of the choroid) were quantitatively evaluated by means of swept-source optical coherence tomography (Triton Ver.10.05, Topcon, Tokyo, Japan) before and after LP (5, 60, and 360 min). Each of these structures was manually delineated for measurement before being superimposed to detect any displacement, using peripheral margins of parapapillary structures as a reference plane.
Results
A total of 16 eyes of 8 nonglaucomatous patients were evaluated. The CSF volume was median (IQR), 1.65 mL (1.16 to 2.00) and none of the ONH structures showed any anatomic changes at any time point after LP.
Conclusions
According to the design of this study, diagnostic LP is a safe procedure regarding deep ONH structures in nonglaucomatous subjects.
MeSH Terms
Shields Classification
Key Concepts5
Diagnostic lumbar puncture (LP) is not followed by optic nerve head (ONH) and parapapillary anatomic changes in normal human eyes, as assessed by swept-source optical coherence tomography before and after LP (5, 60, and 360 min).
None of the optic nerve head (ONH) structures showed any anatomic changes at any time point (5, 60, and 360 minutes) after diagnostic lumbar puncture (LP) in 16 eyes of 8 nonglaucomatous patients, with a median CSF volume removed of 1.65 mL (IQR: 1.16 to 2.00 mL).
Diagnostic lumbar puncture (LP) is a safe procedure regarding deep optic nerve head (ONH) structures in nonglaucomatous subjects, based on a prospective, single-center, observational case series.
Optic nerve head (ONH) structures, including the prelaminar tissue surface, anterior surface of the lamina cribrosa, and central retinal vessels, were quantitatively evaluated using swept-source optical coherence tomography (Triton Ver.10.05, Topcon, Tokyo, Japan) before and after diagnostic lumbar puncture.
Parapapillary structures, including the internal limiting membrane, posterior surfaces of the retinal nerve fiber layer and Bruch membrane/retinal pigment epithelium complex, Bruch membrane opening, and posterior surface of the choroid, were quantitatively evaluated using swept-source optical coherence tomography (Triton Ver.10.05, Topcon, Tokyo, Japan) before and after diagnostic lumbar puncture.
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