Macular Ganglion Cell and Retinal Nerve Fiber Layer Thickness in Children With Refractive Errors-An Optical Coherence Tomography Study.
Goh Jody P, Koh Victor, Chan Yiong Huak, Ngo Cheryl
AI Summary
This study found that in children with refractive errors, while some macular ganglion cell-inner plexiform layer (GC-IPL) parameters correlate with axial length, minimum GC-IPL and all retinal nerve fiber layer (RNFL) parameters do not, aiding pediatric glaucoma diagnosis.
Abstract
Purpose
To study the distribution of macular ganglion cell-inner plexiform layer (GC-IPL) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in children with refractive errors.
Materials and methods
Two hundred forty-three healthy eyes from 139 children with refractive error ranging from -10.00 to +5.00 D were recruited from the National University Hospital Eye Surgery outpatient clinic. After a comprehensive ocular examination, refraction, and axial length (AL) measurement (IOLMaster), macular GC-IPL and RNFL thickness values were obtained with a spectral domain Cirrus high definition optical coherence tomography system (Carl Zeiss Meditec Inc.). Only scans with signal strength of >6/10 were included. Correlation between variables was calculated using the Pearson correlation coefficient. A multivariate analysis using mixed models was done to adjust for confounders.
Results
The mean spherical equivalent refraction was -3.20±3.51 D and mean AL was 24.39±1.72 mm. Average, minimum, superior, and inferior GC-IPL were 82.59±6.29, 77.17±9.65, 83.68±6.96, and 81.64±6.70 μm, respectively. Average, superior, and inferior peripapillary RNFL were 99.00±11.45, 123.20±25.81, and 124.24±22.23 μm, respectively. Average, superior, and inferior GC-IPL were correlated with AL (β=-2.056, P-value 0.000; β=-2.383, P-value 0.000; β=-1.721, P-value 0.000), but minimum GC-IPL was not (β=-1.056, P-value 0.115). None of the RNFL parameters were correlated with AL.
Conclusions
This study establishes normative macular GC-IPL and RNFL thickness in children with refractive errors. Our results suggest that high definition optical coherence tomography RNFL parameters and minimum GC-IPL are not affected by AL or myopia in children, and therefore warrants further evaluation in pediatric glaucoma patients.
MeSH Terms
Shields Classification
Key Concepts6
In children with refractive errors, average, superior, and inferior macular ganglion cell-inner plexiform layer (GC-IPL) thicknesses were correlated with axial length (β=-2.056, P-value 0.000; β=-2.383, P-value 0.000; β=-1.721, P-value 0.000), but minimum GC-IPL was not (β=-1.056, P-value 0.115), in a study of 243 healthy eyes from 139 children.
In children with refractive errors, none of the peripapillary retinal nerve fiber layer (RNFL) parameters were correlated with axial length in a study of 243 healthy eyes from 139 children.
High definition optical coherence tomography retinal nerve fiber layer (RNFL) parameters and minimum macular ganglion cell-inner plexiform layer (GC-IPL) are not affected by axial length or myopia in children, warranting further evaluation in pediatric glaucoma patients, based on a study of 243 healthy eyes from 139 children with refractive errors.
In children with refractive errors, the mean spherical equivalent refraction was -3.20±3.51 D and mean axial length (AL) was 24.39±1.72 mm in a study of 243 healthy eyes from 139 children.
In children with refractive errors, average, minimum, superior, and inferior macular ganglion cell-inner plexiform layer (GC-IPL) thicknesses were 82.59±6.29, 77.17±9.65, 83.68±6.96, and 81.64±6.70 μm, respectively, in a study of 243 healthy eyes from 139 children.
In children with refractive errors, average, superior, and inferior peripapillary retinal nerve fiber layer (RNFL) thicknesses were 99.00±11.45, 123.20±25.81, and 124.24±22.23 μm, respectively, in a study of 243 healthy eyes from 139 children.
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