The distribution of retinal nerve fiber layer thickness and associations with age, refraction, and axial length: the Gutenberg health study.
Hoffmann Esther M, Schmidtmann Irene, Siouli Angeliki, Schuster Alexander K, Beutel Manfred E, Pfeiffer Norbert, Lamparter Julia
AI Summary
This study found pRNFL thickness decreases with age and longer eyes, but is independent of sex, IOP, or CCT, aiding glaucoma diagnosis interpretation.
Abstract
Purpose
To evaluate the distribution of peripapillary retinal nerve fiber layer thickness as measured by optical coherence tomography and its associations with ocular parameters in a population-based setting.
Methods
In the population-based Gutenberg Health Study, 1974 subjects from the Mainz-Bingen region were scheduled for ophthalmologic examinations, including visual acuity, refraction, tonometry, biometry, and measurements of peripapillary retinal nerve fiber layer thickness (pRNFL) by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany). The associated factors in the global and sectoral pRNFL data were analyzed using multivariable linear mixed models related to age, sex, and ocular parameters.
Results
Advanced age and longer axial length were associated with a thinner pRNFL, whereas pRNFL thickness was independent of sex, intraocular pressure (IOP), and central corneal thickness (CCT). Spherical equivalent was positively associated with pRNFL thickness, except in the temporal pRNFL sector.
Conclusions
In this large, population-based study, pRNFL thickness decreased with age. Longer eyes had thinner pRNFL thickness. Sex, IOP, and CCT showed no significant association with pRNFL thickness. These data may improve the interpretation of pRNFL data.
MeSH Terms
Shields Classification
Key Concepts4
In a population-based Gutenberg Health Study of 1974 subjects from the Mainz-Bingen region, advanced age was associated with a thinner peripapillary retinal nerve fiber layer (pRNFL) thickness as measured by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany).
In a population-based Gutenberg Health Study of 1974 subjects from the Mainz-Bingen region, longer axial length was associated with a thinner peripapillary retinal nerve fiber layer (pRNFL) thickness as measured by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany).
In a population-based Gutenberg Health Study of 1974 subjects from the Mainz-Bingen region, peripapillary retinal nerve fiber layer (pRNFL) thickness was independent of sex, intraocular pressure (IOP), and central corneal thickness (CCT) as measured by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany).
In a population-based Gutenberg Health Study of 1974 subjects from the Mainz-Bingen region, spherical equivalent was positively associated with peripapillary retinal nerve fiber layer (pRNFL) thickness, except in the temporal pRNFL sector, as measured by optical coherence tomography (SD-OCT, Spectralis®, Heidelberg Engineering, Germany).
Related Articles5
Sleep Disturbance as a Risk Factor for Retinal Neurodegeneration and Subsequent Glaucoma.
Observational StudyComparison of Deep Learning and Clinician Performance for Detecting Referable Glaucoma from Fundus Photographs in a Safety Net Population.
Cohort StudyEarly ophthalmological tumour signs and diagnostic interval in children with brain tumours.
Cohort StudyClinical and anatomical features of myopia.
ReviewCharacterization of Peripapillary Hyperreflective Ovoid Mass-like Structures in a Broad Spectrum of Neurologic Disorders.
Cohort StudyIs this article assigned to the wrong chapter(s)? Let us know.