Consistency of Structure-Function Correlation Between Spatially Scaled Visual Field Stimuli and In Vivo OCT Ganglion Cell Counts.
Yoshioka Nayuta, Zangerl Barbara, Phu Jack, Choi Agnes Y J, Khuu Sieu K, Masselos Katherine, Hennessy Michael P, Kalloniatis Michael
AI Summary
This study found smaller visual field stimuli (GI-GII) better correlate central retinal structure (ganglion cells) and function in normal and early glaucoma eyes, suggesting this relationship is governed by ganglion cell density.
Abstract
Purpose
To investigate the effect of stimulus size and disease status on the structure-function relationship within the central retina, we correlated the differential light sensitivity (DLS) with Goldmann stimulus size I to V (GI-V) and optical coherence tomography (OCT) derived in vivo ganglion cell count per stimulus area (GCc) within the macular area in normal subjects and patients with early glaucoma.
Methods
Humphrey Field Analyzer 10-2 visual field data with GI through V and Spectralis OCT macular ganglion cell layer (GCL) thickness measurements were collected from normal and early glaucoma cohorts including 25 subjects each. GCc was calculated from GCL thickness data and correlated with DLSs for different stimulus sizes.
Results
Correlation coefficients attained with smaller stimulus size were higher compared to larger stimulus sizes in both normal (GI-GII: R2 = 0.41-0.43, GIII-GV: R2 = 0.16-0.41) and diseased cohorts (GI-GII: R2 = 0.33-0.41, GIII-GV: R2 = 0.19-0.36). Quadratic regression curves for combined GI to V data demonstrated high correlation (R2= 0.82-0.90) and differed less than 1 dB of visual sensitivity within the GCc range between cohorts. The established structure-function relationship was compatible with a histologically derived model correlation spanning the range predicted by stimulus sizes GI to GIII.
Conclusions
Stimulus sizes within critical spatial summation area (GI-II) improved structure-function correlations in the central visual field. The structure-function relationship was identical in both normal and diseased cohort when GI to GV data were combined. Congruency of GI and GII structure-function correlation with those previously derived with GIII from more peripheral locations further suggests that the structure-function relationship is governed by the number of ganglion cell per stimulus area.
MeSH Terms
Shields Classification
Key Concepts6
In a cross-sectional study of 25 normal subjects and 25 patients with early glaucoma, correlation coefficients between differential light sensitivity (DLS) and optical coherence tomography (OCT) derived in vivo ganglion cell count per stimulus area (GCc) were higher for smaller stimulus sizes (Goldmann stimulus sizes GI-GII: R2 = 0.41-0.43 in normal subjects, R2 = 0.33-0.41 in diseased cohorts) compared to larger stimulus sizes (GIII-GV: R2 = 0.16-0.41 in normal subjects, R2 = 0.19-0.36 in diseased cohorts).
In a cross-sectional study of 25 normal subjects and 25 patients with early glaucoma, quadratic regression curves combining Goldmann stimulus sizes GI to V data demonstrated high correlation (R2= 0.82-0.90) between differential light sensitivity (DLS) and optical coherence tomography (OCT) derived in vivo ganglion cell count per stimulus area (GCc).
In a cross-sectional study of 25 normal subjects and 25 patients with early glaucoma, the established structure-function relationship, when combining Goldmann stimulus sizes GI to V data, differed by less than 1 dB of visual sensitivity within the ganglion cell count per stimulus area (GCc) range between normal and diseased cohorts.
In a cross-sectional study of 25 normal subjects and 25 patients with early glaucoma, stimulus sizes within the critical spatial summation area (Goldmann stimulus sizes GI-II) improved structure-function correlations in the central visual field.
In a cross-sectional study of 25 normal subjects and 25 patients with early glaucoma, the structure-function relationship was identical in both normal and diseased cohorts when Goldmann stimulus sizes GI to GV data were combined.
In a cross-sectional study of 25 normal subjects and 25 patients with early glaucoma, the congruency of Goldmann stimulus sizes GI and GII structure-function correlation with those previously derived with GIII from more peripheral locations suggests that the structure-function relationship is governed by the number of ganglion cells per stimulus area.
Related Articles5
Evaluation of visual function and OCT parameters in ethambutol-induced optic neuropathy: a longitudinal study.
Cohort StudyPrimary Visual Pathway Changes in Individuals With Chronic Mild Traumatic Brain Injury.
Case-Control StudyStructure-Function Associations Between Quantitative Contrast Sensitivity Function And Peripapillary Optical Coherence Tomography Angiography in Diabetic Retinopathy.
Cross-Sectional StudyRelating Standardized Automated Perimetry Performed With Stimulus Sizes III and V in Eyes With Field Loss Due to Glaucoma and NAION.
Observational StudyHigh-Resolution Microperimetry for Detecting Glaucomatous Damage: A Prospective Evaluation of Performance.
Prospective StudiesIs this article assigned to the wrong chapter(s)? Let us know.