Progression of Primary Open-Angle Glaucoma in Diabetic and Nondiabetic Patients.
Hou Huiyuan, Shoji Takuhei, Zangwill Linda M, Moghimi Sasan, Saunders Luke J, Hasenstab Kyle, Ghahari Elham, Manalastas Patricia Isabel C, Akagi Tadamichi, Christopher Mark
AI Summary
This study found primary open-angle glaucoma patients with treated type 2 diabetes experienced significantly slower retinal nerve fiber layer thinning than non-diabetics, suggesting a unique progression profile.
Abstract
Purpose
To compare the rates of visual field (VF) loss and retinal nerve fiber layer (RNFL) thinning in primary open-angle glaucoma (POAG) patients with or without type 2 diabetes mellitus (DM).
Design
Cohort study.
Methods
A total of 197 eyes (55 eyes of 32 POAG patients with DM in POAG/DM group and 142 eyes of 111 age-matched POAG patients without DM in POAG/DM- group) were included from the Diagnostic Innovations in Glaucoma Study (DIGS). Type 2 DM participants were defined by self-report of DM history and use of antidiabetic medication. The rates of VF loss and RNFL loss were compared in POAG eyes with and without DM using univariate and multivariable mixed-effects models.
Results
The median (interquartile range) follow-up was 5.7 years (4.0, 6.4). The mean rate of global RNFL loss in the POAG/DM group was 2-fold slower than in the POAG/DM- group overall (-0.40 μm/year vs -0.83 μm/year, respectively P = .01). Although a slower rate of VF mean deviation and pattern standard deviation loss was found in the POAG/DM group compared to the POAG/DM- group, the difference was not statistically significant.
Conclusions
POAG patients with treated type 2 DM, who had no detectable diabetic retinopathy, had significantly slower rates of RNFL thinning compared to those without diagnosed DM.
MeSH Terms
Shields Classification
Key Concepts4
The mean rate of global retinal nerve fiber layer (RNFL) loss in primary open-angle glaucoma (POAG) patients with type 2 diabetes mellitus (DM) was 2-fold slower (-0.40 μm/year) than in POAG patients without DM (-0.83 μm/year, P = .01).
Primary open-angle glaucoma (POAG) patients with treated type 2 diabetes mellitus (DM), who had no detectable diabetic retinopathy, had significantly slower rates of retinal nerve fiber layer (RNFL) thinning compared to those without diagnosed DM.
A slower rate of visual field (VF) mean deviation and pattern standard deviation loss was found in primary open-angle glaucoma (POAG) patients with type 2 diabetes mellitus (DM) compared to those without DM, but the difference was not statistically significant.
This cohort study included 197 eyes (55 eyes of 32 primary open-angle glaucoma (POAG) patients with type 2 diabetes mellitus (DM) and 142 eyes of 111 age-matched POAG patients without DM) from the Diagnostic Innovations in Glaucoma Study (DIGS) with a median follow-up of 5.7 years (interquartile range: 4.0, 6.4).
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