Amore Giulia

Coutinho Catarina P, Zanchetta Ferdinando, Carbonelli Michele, Battista Marco, Galzignato Alice, La Morgia Chiara et al.

Machine learning identified characteristic visual field patterns in dominant optic atrophy, showing central/ceco-central defects are common. This tool can objectively quantify disease progression and link genotype to functional severity.

Amore Giulia, Romagnoli Martina, Carbonelli Michele, Cascavilla Maria Lucia, De Negri Anna Maria, Carta Arturo et al.

This study compared AFG3L2, ACO2, and OPA1-related Dominant Optic Atrophy. ACO2-DOA showed better retinal ganglion cell preservation than AFG3L2/OPA1-DOA, implying different disease mechanisms despite similar clinical presentation.

Barboni Piero, La Morgia Chiara, Cascavilla Maria Lucia, Hong Eun Hee, Battista Marco, Majander Anna et al.

Studying childhood-onset LHON, researchers found children losing vision before age 9 had a better visual prognosis than older children, suggesting a milder disease form.

Carbonelli Michele, La Morgia Chiara, Romagnoli Martina, Amore Giulia, D'Agati Pietro, Valentino Maria Lucia et al.

OCT showed that in LHON, presymptomatic optic nerve thickening in sector 8 is followed by its thinning, marking the transition to affected status, a key structural biomarker for early detection.

Barboni Piero, Amore Giulia, Cascavilla Maria Lucia, Battista Marco, Frontino Giulio, Romagnoli Martina et al.

This study found Wolfram Syndrome causes more severe, faster visual pathway degeneration than OPA1-DOA, with axonal loss preceding cell body loss, suggesting different underlying disease mechanisms.

Calzetti Giacomo, La Morgia Chiara, Cattaneo Marco, Carta Arturo, Bosello Francesca, Amore Giulia et al.

This study found early LHON involves increased optic disk blood flow before structural nerve loss, then perfusion drops. This suggests optic disk perfusion is a promising biomarker for LHON diagnosis and monitoring.