Cole Brian S

Zebardast Nazlee, Sekimitsu Sayuri, Wang Jiali, Elze Tobias, Gharahkhani Puya, Cole Brian S et al.

This study found 25% of MYOC p.Gln368Ter carriers had glaucoma, often undiagnosed and with normal IOP. Polygenic risk scores increased penetrance and severity, highlighting their utility for risk stratification.

Cole Brian S, Gudiseva Harini V, Pistilli Maxwell, Salowe Rebecca, McHugh Caitlin P, Zody Michael C et al.

Studying African Americans, higher African genetic ancestry was associated with increased primary open-angle glaucoma risk. This highlights the importance of genetic background in assessing glaucoma susceptibility.