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Lin Michael M

πŸ‡΄πŸ‡² Massachusetts Institute of Technology
ORCIDOpenAlex12 articles in GJC

12 articles in GJC

6.

Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank.

Zebardast Nazlee, Sekimitsu Sayuri, Wang Jiali, Elze Tobias, Gharahkhani Puya, Cole Brian S et al.

OphthalmologyMar 202131 citationsCross-Sectional Study

This study found 25% of MYOC p.Gln368Ter carriers had glaucoma, often undiagnosed and with normal IOP. Polygenic risk scores increased penetrance and severity, highlighting their utility for risk stratification.

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