Dang Yalong

Waxman Susannah, Strzalkowska Alicja, Wang Chao, Loewen Ralitsa, Dang Yalong, Loewen Nils A

Tissue-engineered eye cultures reseeded with trabecular meshwork cells restored normal outflow and IOP regulation. This offers a scalable model for glaucoma research, reducing reliance on donor eyes.

Wang Chao, Dang Yalong, Waxman Susannah, Hong Ying, Shah Priyal, Loewen Ralitsa T et al.

Ripasudil (K-115) was studied in a pigmentary glaucoma model, showing it reduced stress fibers, restored trabecular meshwork function, and normalized intraocular pressure, suggesting its potential for pigmentary glaucoma treatment.

Wang Chao, Dang Yalong, Loewen Ralitsa T, Waxman Susannah, Shah Priyal, Xia Xiaobo et al.

Pigment dispersion impairs trabecular meshwork cell function via Rho signaling, suggesting Rho inhibitors could treat pigmentary glaucoma by improving outflow.

Dang Yalong, Wang Chao, Shah Priyal, Waxman Susannah, Loewen Ralitsa T, Loewen Nils A

RKI-1447, a Rho kinase inhibitor, effectively lowered IOP in a pig pigmentary glaucoma model by disrupting trabecular meshwork stress fibers and enhancing phagocytosis, suggesting its potential for secondary glaucomas.

Waxman Susannah, Wang Chao, Dang Yalong, Hong Ying, Esfandiari Hamed, Shah Priyal et al.

Nitric oxide dilated distal outflow vessels and increased fluid outflow in porcine eyes, even after trabeculectomy. This suggests NO-mediated distal outflow vessel dilation is a promising glaucoma treatment target.

Dang Yalong, Wang Chao, Shah Priyal, Waxman Susannah, Loewen Ralitsa T, Hong Ying et al.

This study compared three ab interno trabeculectomy devices, finding Trabectome provided superior outflow enhancement in a porcine model, suggesting varying efficacy for glaucoma surgery.

Waxman Susannah, Loewen Ralitsa T, Dang Yalong, Watkins Simon C, Watson Alan M, Loewen Nils A

Studying cleared pig eyes, researchers found regional differences in glaucoma outflow structures; collector channels were largest nasally, while scleral vascular plexus was largest inferiorly, explaining varied outflow rates.

Dang Yalong, Kaplowitz Kevin, Parikh Hardik A, Roy Pritha, Loewen Ralitsa T, Francis Brian A et al.

Trabectome surgery effectively lowered intraocular pressure in steroid-induced glaucoma patients, achieving greater IOP reduction than in POAG, making it a viable treatment option.