Dosa Peter I

Pervan-Steel Cynthia L, Roy Chowdhury Uttio, Sookdeo Hemchand K, Casale Ralph A, Dosa Peter I, Htoo Thurein M et al.

QLS-101, a novel prodrug, effectively lowered eye pressure in mice for 24 hours after daily topical application, converting to its active form in human eye tissues. This offers a new glaucoma treatment.

Roy Chowdhury Uttio, Millar J Cameron, Holman Bradley H, Anderson Kjersten J, Dosa Peter I, Roddy Gavin W et al.

ATP-sensitive potassium channel openers (CKLP1, diazoxide) effectively lowered intraocular pressure in ocular hypertensive mouse models by decreasing episcleral venous pressure, suggesting a new glaucoma treatment approach.

Roy Chowdhury Uttio, Rinkoski Tommy A, Bahler Cindy K, Millar J Cameron, Bertrand Jacques A, Holman Bradley H et al.

CKLP1, a novel drug, lowers eye pressure by reducing episcleral venous pressure and distal outflow resistance. Its unique mechanism allows additive pressure reduction when combined with existing glaucoma medications, offering new treatment options.