Frishman Laura J

Patel Nimesh B, Carter-Dawson Louvenia, Frishman Laura J

Transient IOP challenges revealed that baseline optic nerve features and axial elongation predict the extent of retinal ganglion cell loss in experimental glaucoma, suggesting potential for early risk assessment.

Wang Jing, Cheng Han, Hu Ying-Sheng, Tang Rosa A, Frishman Laura J

MS patients show reduced ERG PhNR, indicating inner retinal dysfunction even without optic neuritis. This correlates with visual field loss and RNFL thinning, suggesting PhNR as a clinical biomarker for MS-related retinal damage.

Luo Xunda, Frishman Laura J

This study found PERG signals originate from both ON and OFF retinal pathways, with N95 reflecting ganglion cell spiking and P50 non-spiking activity, crucial for glaucoma diagnosis.

Luo Xunda, Patel Nimesh B, Harwerth Ronald S, Frishman Laura J

Primate glaucoma caused a dramatic loss of low-frequency mfERG signals, which correlated with retinal nerve fiber layer thickness and visual field sensitivity. This offers an objective way to monitor early glaucoma.

Akimov Nikolay P, Marshak David W, Frishman Laura J, Glickman Randolph D, Yusupov Rafail G

Histamine reduces primate ON retinal ganglion cell sensitivity to light flashes, potentially explaining why humans are less sensitive to dim light during the day.

Cheng Han, Laron Michal, Schiffman Jade S, Tang Rosa A, Frishman Laura J

This study investigated visual field and RNFL thickness in MS patients, finding good agreement between these measures in eyes with prior optic neuritis, but less in non-ON eyes or at a sectoral level, supporting combined testing for MS research.

Rangaswamy Nalini V, Shirato Suguru, Kaneko Muneyoshi, Digby Beth I, Robson John G, Frishman Laura J

This study identified optimal flash and background colors for maximizing the glaucoma-sensitive PhNR signal in ERG. Red flashes on blue backgrounds best isolated PhNR, improving early glaucoma detection.

Rangaswamy Nalini V, Zhou Wei, Harwerth Ronald S, Frishman Laura J

Experimental glaucoma in primates reduced fast mfERG oscillatory potentials, even with moderate vision loss, suggesting their utility for early glaucoma monitoring and treatment assessment.

Rangaswamy Nalini V, Frishman Laura J, Dorotheo E Ulysses, Schiffman Jade S, Bahrani Hasan M, Tang Rosa A

This study found the photopic negative response (PhNR) is significantly reduced in human optic neuropathies, reflecting ganglion cell loss. This reduction correlates with visual field defects, making PhNR a potential biomarker for optic nerve damage.

Harwerth Ronald S, Crawford M L J, Frishman Laura J, Viswanathan Suresh, Smith Earl L, Carter-Dawson Louvenia

Monkey glaucoma research showed visual field defects link to retinal detection loss, neural metabolism broadly reduces, and electrophysiology is as sensitive as perimetry for assessing neural damage.