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Electrophysiological and histologic assessment of retinal ganglion cell fate in a mouse model for OPA1-associated autosomal dominant optic atrophy.
Heiduschka Peter, Schnichels Sven, Fuhrmann Nico, Hofmeister Sabine, Schraermeyer Ulrich, Wissinger Bernd et al.
Invest Ophthalmol Vis SciMar 201056 citationsBasic Science
This mouse study on OPA1-ADOA found significant RGC loss and reduced VEP amplitudes, but normal RGC function and ERG. This suggests RGC death, not dysfunction, is key, guiding future ADOA therapies.