Wissinger Bernd

Kölz Charlotte, Neul Claudia, Hofmann Ute, Dressler Julia C, Süsskind Daniela, Wissinger Bernd et al.

Brimonidine is transported by ocular OCT2 and MATE1. Their presence in key anterior eye structures suggests they mediate brimonidine uptake, potentially explaining interindividual treatment response variability.

Simcoe Mark J, Weisschuh Nicole, Wissinger Bernd, Hysi Pirro G, Hammond Christopher J

This study found pigmentary glaucoma is highly heritable, with genetic links to lighter eye color and myopia, suggesting genetic predisposition for this severe glaucoma.

González-Menéndez Irene, Reinhard Katja, Tolivia Jorge, Wissinger Bernd, Münch Thomas A

This study found Opa1 mutations preferentially damage small-axon RGCs in ADOA, causing luminance-dependent functional changes. Melanopsin-independent RGCs are protected, suggesting complex disease mechanisms beyond RGC type.

Fahim Abigail T, Khan Naheed W, Zahid Sarwar, Schachar Ira H, Branham Kari, Kohl Susanne et al.

Achromatopsia patients show age-dependent FAF patterns; foveal hyperfluorescence is an early diagnostic sign, progressing to hypofluorescence with atrophy, aiding early diagnosis and tracking disease progression.

Heiduschka Peter, Schnichels Sven, Fuhrmann Nico, Hofmeister Sabine, Schraermeyer Ulrich, Wissinger Bernd et al.

This mouse study on OPA1-ADOA found significant RGC loss and reduced VEP amplitudes, but normal RGC function and ERG. This suggests RGC death, not dysfunction, is key, guiding future ADOA therapies.

Wolf Christiane, Gramer Eugen, Müller-Myhsok Bertram, Pasutto Francesca, Gramer Gwendolyn, Wissinger Bernd et al.

LOXL1 gene polymorphisms were studied in German glaucoma patients. They were strongly linked to exfoliation glaucoma, but not significantly to normal tension or pigmentary glaucoma, except for one variant affecting pigmentary glaucoma onset age.

Weisschuh Nicole, Wolf Christiane, Wissinger Bernd, Gramer Eugen

This study found that only 18% of German PCG patients have CYP1B1 mutations, indicating it's a minor genetic cause in this population, relevant for genetic counseling and research.

Renner Agnes B, Tillack Hilmar, Kraus Hannelore, Kohl Susanne, Wissinger Bernd, Mohr Nicole et al.

This study characterized adult vitelliform macular dystrophy (AVMD), finding it's a variable condition with late onset, slow progression, and frequent cone dysfunction, often leading to misdiagnosis.

Pesch Ulrike E A, Fries Julia E, Bette Stefanie, Kalbacher Hubert, Wissinger Bernd, Alexander Christiane et al.

OPA1, linked to dominant optic atrophy, was found specifically in retinal ganglion, starburst amacrine, and horizontal cells. This suggests OPA1 is crucial for retinal signal processing, not just optic nerve integrity.