Kalbacher Hubert

🇣🇤 University of Tübingen

2 articles in GJC

Alterations of amino acids and glutamate transport in the DBA/2J mouse retina; possible clues to degeneration.

Schuettauf Frank, Thaler Sebastian, Bolz Sylvia, Fries Julia, Kalbacher Hubert, Mankowska Anna et al.

Graefes Arch Clin Exp OphthalmolAug 200728 citationsBasic Science

This study found increased retinal amino acids, including glutamate, and decreased glutamate transporters in glaucoma-prone DBA/2J mice, suggesting excitotoxicity contributes to RGC loss.

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OPA1, the disease gene for autosomal dominant optic atrophy, is specifically expressed in ganglion cells and intrinsic neurons of the retina.

Pesch Ulrike E A, Fries Julia E, Bette Stefanie, Kalbacher Hubert, Wissinger Bernd, Alexander Christiane et al.

Invest Ophthalmol Vis SciNov 200444 citationsBasic Science

OPA1, linked to dominant optic atrophy, was found specifically in retinal ganglion, starburst amacrine, and horizontal cells. This suggests OPA1 is crucial for retinal signal processing, not just optic nerve integrity.

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Kalbacher Hubert

Alterations of amino acids and glutamate transport in the DBA/2J mouse retina; possible clues to degeneration.

OPA1, the disease gene for autosomal dominant optic atrophy, is specifically expressed in ganglion cells and intrinsic neurons of the retina.