Gerometta Rosana

Gerometta Rosana, Kumar Sandeep, Shah Shaily, Alvarez Larry, Candia Oscar, Danias John

In sheep, tissue plasminogen activator (tPA) effectively prevented and reversed steroid-induced intraocular pressure elevation. This suggests tPA could be a therapeutic agent for steroid-induced glaucoma in humans.

Gerometta Rosana, Alvarez Lawrence J, Candia Oscar A

Sildenafil accelerated anterior chamber refilling in sheep and rabbits, suggesting potential clinical utility for enhancing fluid entry after eye surgery or in ocular hypotony.

Danias John, Gerometta Rosana, Ge Yongchao, Ren Lizhen, Panagis Lampros, Mittag Thomas W et al.

Steroid-induced IOP elevation in cow eyes alters gene expression in the trabecular meshwork, identifying molecular changes relevant to open-angle glaucoma mechanisms.

Tektas Ozan-Yüksel, Hammer Christian Manfred, Danias John, Candia Oscar, Gerometta Rosana, Podos Steven M et al.

Corticosteroids induced extracellular matrix (collagen VI) accumulation in bovine trabecular meshwork, mimicking human glaucoma changes. This model is useful for studying glaucoma pathogenesis.

Gerometta Rosana, Spiga Maria-Grazia, Borrás Teresa, Candia Oscar A

Gene therapy using an inducible MMP1 virus effectively prevented and reversed steroid-induced high eye pressure in sheep, offering a promising new treatment for steroid-glaucoma.

Gerometta Rosana, Alvarez Lawrence J, Candia Oscar A

Sildenafil and tadalafil increased sheep IOP and aqueous humor protein, suggesting fluid leakage. This highlights potential glaucoma risk for elderly patients using these vasodilators.

Gerometta Rosana, Podos Steven M, Danias John, Candia Oscar A

Topical steroids reliably caused ocular hypertension in sheep, peaking at 27.5 mmHg. This robust model can provide insights into steroid-induced and primary open-angle glaucoma mechanisms and treatments.