Lütjen-Drecoll Elke

Bertrand Jacques A, Schicht Martin, Stamer W Daniel, Baker David, Sherwood Joseph M, Lütjen-Drecoll Elke et al.

This study found the β4-subunit of KCa1.1 channels significantly regulates aqueous humor outflow, suggesting targeting these channels could be a novel glaucoma treatment to lower intraocular pressure.

Gabelt B'ann T, Rasmussen Carol A, Tektas Ozan Y, Kim Charlene B Y, Peterson John C, Nork T Michael et al.

GDx VCC effectively detected early structural changes in experimental glaucoma, correlating with axon loss. Memantine showed potential neuroprotective effects, preserving visual function despite similar IOP exposure.

Birke Marco T, Birke Kerstin, Lütjen-Drecoll Elke, Schlötzer-Schrehardt Ursula, Hammer Christian M

This study found IL-1 lowered eye pressure and increased ELAM-1 in porcine eyes, effects counteracted by TGF-β2. This suggests IL-1/TGF-β2 balance may regulate eye pressure, relevant for glaucoma.

Tektas Ozan-Yueksel, Lütjen-Drecoll Elke, Scholz Michael

This study found that primary open-angle glaucoma causes significant thickening of central optic nerve head capillary sheaths, potentially impairing neuronal nutrition.

Tektas Ozan-Yüksel, Hammer Christian Manfred, Danias John, Candia Oscar, Gerometta Rosana, Podos Steven M et al.

Corticosteroids induced extracellular matrix (collagen VI) accumulation in bovine trabecular meshwork, mimicking human glaucoma changes. This model is useful for studying glaucoma pathogenesis.

Birke Kerstin, Lütjen-Drecoll Elke, Kerjaschki Dontscho, Birke Marco T

This study found podoplanin (Pdpn) and other lymphatic markers on anterior eye cells, notably in the trabecular meshwork and iris. This suggests a role in immune cell trafficking and conventional outflow, impacting glaucoma understanding.

Scholz Michael, Buder Thomas, Seeber Silke, Adamek Edyta, Becker Cord-Michael, Lütjen-Drecoll Elke

This study compared two mouse strains, finding D2J mice develop glaucoma without a direct IOP-damage correlation, while D2Rj mice have high IOP but no glaucoma. This highlights glaucoma's multifactorial nature beyond just IOP.

Nilsson Siv F E, Drecoll Enken, Lütjen-Drecoll Elke, Toris Carol B, Krauss Achim H-P, Kharlamb Alexander et al.

Butaprost, an EP2 agonist, lowered monkey eye pressure by increasing uveoscleral outflow and altering ciliary muscle morphology. This suggests a new therapeutic approach for glaucoma.

Bachmann Bjoern, Birke Marco, Kook Daniel, Eichhorn Michael, Lütjen-Drecoll Elke

This study validated a porcine eye model for glaucoma research, finding its outflow pathway architecture and response to TGF-beta2 (a glaucoma-relevant factor) mirrored human eyes, making it a reliable model.

Gottanka Johannes, Johnson Douglas H, Grehn Franz, Lütjen-Drecoll Elke

This study found pigmentary glaucoma involves trabecular cell loss, lamellar fusion, and extracellular material increase in the meshwork, contributing to elevated IOP. Surgical specimens may underrepresent these changes due to artifacts.

Fuchshofer Rudolf, Welge-Lüssen Ulrich, Lütjen-Drecoll Elke, Birke Marco

Cribriform and corneoscleral TM cells express similar basement membrane components and connect to the elastic network, suggesting mechanical tension. This impacts understanding of outflow regulation and glaucoma pathology.

Gottanka Johannes, Kuhlmann Alexander, Scholz Michael, Johnson Douglas H, Lütjen-Drecoll Elke

Studying optic nerves, POAG showed distinct fibrosis and decreased capillary density compared to PEXG, suggesting additional factors beyond IOP contribute to POAG's nerve damage.

Fuchshofer Rudolf, Birke Marco, Welge-Lussen Ulrich, Kook Daniel, Lütjen-Drecoll Elke

TGF-beta 2 upregulates extracellular matrix components in optic nerve head astrocytes, partly via CTGF. This suggests TGF-beta 2 contributes to glaucoma's optic nerve changes.

May Christian Albrecht, Lütjen-Drecoll Elke

Glaucoma eyes showed a significant loss of choroidal ganglion cells, particularly near the optic nerve, suggesting impaired blood flow regulation to this critical area.

Gottanka Johannes, Chan Darren, Eichhorn Michael, Lütjen-Drecoll Elke, Ethier C Ross

This study found TGF-beta2 perfusion in human eyes reduced outflow facility and altered trabecular meshwork structure, supporting its role in glaucoma's elevated eye pressure.

Richter Markus, Krauss Achim H-P, Woodward David F, Lütjen-Drecoll Elke

Long-term use of prostaglandin analogs/prostamide in primates enlarged uveoscleral outflow pathways, affected conventional outflow, and induced nerve sprouting, explaining their IOP-lowering mechanism.

Gabelt B'Ann True, Gottanka Johannes, Lütjen-Drecoll Elke, Kaufman Paul L

In rhesus monkeys, aging reduced uveoscleral outflow and altered trabecular meshwork/ciliary muscle morphology. These findings mirror human aging, suggesting mechanisms for age-related glaucoma risk.