Schlötzer-Schrehardt Ursula

Pulasani Sai, Zenkel Matthias, Lämmer Robert, Jünemann Anselm, Gießl Andreas, Korn Klaus et al.

Researchers developed an in vitro model using PEX patient fibroblasts that successfully replicated key PEX fibrillar aggregates. This model offers a valuable tool for studying disease mechanisms and testing new therapies for PEX glaucoma.

Schlötzer-Schrehardt Ursula, Khor Chiea Chuen

This review explored PEX glaucoma genetics, finding LOXL1 is key, but other genes highlight pathways like elastin, calcium, and lipid metabolism, offering targets for future therapies.

Berner Daniel, Zenkel Matthias, Pasutto Francesca, Hoja Ursula, Liravi Panah, Gusek-Schneider Gabriele C et al.

This study found that alternative splicing and NMD regulate LOXL1 expression, adapting it to PEX-associated stresses, which may explain LOXL1's role in pseudoexfoliation glaucoma.

Schlötzer-Schrehardt Ursula, Hammer Christian M, Krysta Anita W, Hofmann-Rummelt Carmen, Pasutto Francesca, Sasaki Takako et al.

LOXL1 deficiency and elastic fiber disruption in the lamina cribrosa of pseudoexfoliation eyes create an elastinopathy, increasing glaucoma risk by making the optic nerve vulnerable to damage.

Braunsmann Christoph, Hammer Christian M, Rheinlaender Johannes, Kruse Friedrich E, Schäffer Tilman E, Schlötzer-Schrehardt Ursula

This study found lamina cribrosa and peripapillary sclera in pseudoexfoliation eyes were significantly softer than normal. This increased deformability may explain why PEX eyes are more vulnerable to glaucomatous damage.

Krueger Bettina, Schlötzer-Schrehardt Ursula, Haerteis Silke, Zenkel Matthias, Chankiewitz Verena E, Amann Kerstin U et al.

This study found all four ENaC subunits are widely expressed in normal human eye tissues, including cornea, ciliary body, and retina, with distinct protein localization. No ENaC mRNA changes were seen in glaucoma, suggesting potential roles in ocular fluid dynamics, but further research is needed.

Birke Marco T, Birke Kerstin, Lütjen-Drecoll Elke, Schlötzer-Schrehardt Ursula, Hammer Christian M

This study found IL-1 lowered eye pressure and increased ELAM-1 in porcine eyes, effects counteracted by TGF-β2. This suggests IL-1/TGF-β2 balance may regulate eye pressure, relevant for glaucoma.

Rössler Christopher W, Baleanu Delia, Reulbach Udo, Lewczuk Piotr, Bleich Stefan, Kruse Friedrich E et al.

This study found no link between elevated plasma homocysteine levels and normal tension glaucoma, suggesting homocysteine is unlikely a modifiable risk factor for NTG.

Krumbiegel Mandy, Pasutto Francesca, Mardin Christian Y, Weisschuh Nicole, Paoli Daniela, Gramer Eugen et al.

This study found no association between APOE genotypes and pseudoexfoliation syndrome or glaucoma in German and Italian populations, suggesting APOE is not a genetic risk factor for these conditions.

Kraft Michaela E, Glaeser Hartmut, Mandery Kathrin, König Jörg, Auge Daniel, Fromm Martin F et al.

This study found OATP2A1 transports latanoprost acid and is highly expressed in human ocular tissues, suggesting it's crucial for latanoprost's intraocular action and may explain variable patient responses.

Krumbiegel Mandy, Pasutto Francesca, Mardin Christian Y, Weisschuh Nicole, Paoli Daniela, Gramer Eugen et al.

This study found a CLU gene variant (rs2279590) associated with PEX syndrome in Germans, but not Italians, suggesting population-specific genetic risk for this glaucoma-related condition.

Pasutto Francesca, Krumbiegel Mandy, Mardin Christian Y, Paoli Daniela, Lämmer Robert, Weber Bernhard H F et al.

This study confirmed LOXL1 gene variants are strongly associated with pseudoexfoliation and glaucoma in German/Italian patients, reinforcing its global role in disease risk.

Zenkel Matthias, Kruse Friedrich E, Naumann Gottfried O H, Schlötzer-Schrehardt Ursula

This study found pseudoexfoliation eyes have impaired cytoprotective mechanisms (e.g., antioxidant defense, DNA repair). This vulnerability to stress may contribute to pseudoexfoliation syndrome's pathology.

Roedl Johannes B, Bleich Stefan, Reulbach Udo, Rejdak Robert, Kornhuber Johannes, Kruse Friedrich E et al.

PEXG patients showed significantly higher homocysteine in tears and plasma, suggesting its potential role in PEXG's ocular and systemic manifestations.

Zenkel Matthias, Kruse Friedrich E, Jünemann Anselm G, Naumann Gottfried O H, Schlötzer-Schrehardt Ursula

Clusterin deficiency in the anterior segment of pseudoexfoliation (PEX) eyes was found, suggesting this reduction may promote the aggregation and deposition of the characteristic PEX material.

Zenkel Matthias, Pöschl Ernst, von der Mark Klaus, Hofmann-Rummelt Carmen, Naumann Gottfried O H, Kruse Friedrich E et al.

This study found PEX glaucoma eyes have altered gene expression in anterior segment tissues, notably increased elastic microfibril components and stress-related genes, suggesting PEX is a stress-induced elastic microfibrillopathy.

Schlötzer-Schrehardt Ursula, Zenkel Matthias, Decking Ulrich, Haubs Daniela, Kruse Friedrich E, Jünemann Anselm et al.

PEX eyes showed selective, hypoxia-induced A3 adenosine receptor upregulation in ciliary epithelium, suggesting its role in aqueous humor dynamics and potential as a therapeutic target in PEX glaucoma.

Bleich Stefan, Roedl Johannes, Von Ahsen Nicolas, Schlötzer-Schrehardt Ursula, Reulbach Udo, Beck Georg et al.

Pseudoexfoliation glaucoma patients showed significantly elevated aqueous humor homocysteine, suggesting it may contribute to disease pathogenesis by causing vascular injury and extracellular matrix changes.

Moroi Sayoko E, Lark Kurt K, Sieving Paul A, Nouri-Mahdavi Kouros, Schlötzer-Schrehardt Ursula, Katz Gregory J et al.

Long anterior zonules inserting centrally on the lens capsule cause pigment dispersion by mechanically disrupting the iris, leading to glaucoma-related signs without exfoliation material.

Ritch Robert, Schlötzer-Schrehardt Ursula, Konstas Anastasios G P

Exfoliation Syndrome glaucoma stems from abnormal matrix deposition in the trabecular meshwork and Schlemm's canal, plus mechanical factors like iridolenticular friction and lens changes, leading to chronic pressure elevation.

Schlötzer-Schrehardt Ursula, Lommatzsch Jürgen, Küchle Michael, Konstas Anastasios G P, Naumann Gottfried O H

This study found imbalanced MMP-TIMP ratios and reduced active MMP-2 in aqueous humor of PEX and POAG patients. This imbalance may cause abnormal matrix accumulation, contributing to glaucoma pathogenesis.

Koliakos George G, Konstas Anastasios G P, Schlötzer-Schrehardt Ursula, Bufidis Theodoros, Georgiadis Nikolaos, Ringvold Amund

This study found significantly lower aqueous humor ascorbic acid (vitamin C) in exfoliation syndrome patients, suggesting oxidative stress may contribute to the disease's development.