Hofmann-Rummelt Carmen

Schlötzer-Schrehardt Ursula, Hammer Christian M, Krysta Anita W, Hofmann-Rummelt Carmen, Pasutto Francesca, Sasaki Takako et al.

LOXL1 deficiency and elastic fiber disruption in the lamina cribrosa of pseudoexfoliation eyes create an elastinopathy, increasing glaucoma risk by making the optic nerve vulnerable to damage.

Thieme Hagen, Choritz Lars, Hofmann-Rummelt Carmen, Schloetzer-Schrehardt Ursula, Kottler Ulrike B

This study found early encapsulated blebs around Ahmed Glaucoma Valves in young patients are dense, myofibroblastic capsules, not inflammatory. This scar tissue blocks fluid flow, not the valve, and surgical removal restores function.

Zenkel Matthias, Pöschl Ernst, von der Mark Klaus, Hofmann-Rummelt Carmen, Naumann Gottfried O H, Kruse Friedrich E et al.

This study found PEX glaucoma eyes have altered gene expression in anterior segment tissues, notably increased elastic microfibril components and stress-related genes, suggesting PEX is a stress-induced elastic microfibrillopathy.