Kruse Friedrich E

Pulasani Sai, Zenkel Matthias, Lämmer Robert, Jünemann Anselm, Gießl Andreas, Korn Klaus et al.

Researchers developed an in vitro model using PEX patient fibroblasts that successfully replicated key PEX fibrillar aggregates. This model offers a valuable tool for studying disease mechanisms and testing new therapies for PEX glaucoma.

Huchzermeyer Cord, Lämmer Robert, Mardin Christian Y, Kruse Friedrich E, Kremers Jan, Horn Folkert K

This study found Pattern ERG (PERG) amplitude independently predicts visual field defect development in glaucoma suspects, offering a valuable tool for risk assessment and guiding early intervention.

Galimi Maria E, Weller Julia M, Kruse Friedrich E, Laemmer Robert

XEN Gel Stent implantation commonly causes hypotony. Eyes with longer axial length (>24.3mm) have increased hypotony risk, while simultaneous cataract surgery reduces it, informing patient selection.

Schrems-Hoesl Laura M, Schrems Wolfgang A, Laemmer Robert, Kruse Friedrich E, Mardin Christian Y

This study found Spectralis OCT measurements of optic nerve and RNFL parameters, especially BMO-MRW, are highly precise, though slightly less so in glaucoma eyes, aiding accurate glaucoma detection and progression monitoring.

Schrems Wolfgang A, Schrems-Hoesl Laura M, Laemmer Robert, Kruse Friedrich E, Mardin Christian Y

Edlinger Florian S M, Schrems-Hoesl Laura M, Mardin Christian Y, Laemmer Robert, Kruse Friedrich E, Schrems Wolfgang A

This study found macular ganglion cell layer (mGCL) and retinal nerve fiber layer (mRNFL) thickness measurements are comparable to peripapillary RNFL for glaucoma diagnosis, especially in high-tension cases, offering valuable clinical supplementation.

Diekmann Theresa, Schrems-Hoesl Laura M, Mardin Christian Y, Laemmer Robert, Horn Folkert K, Kruse Friedrich E et al.

This study found that both SLP and SD-OCT similarly predict future visual field conversion in glaucoma, making both useful tools for monitoring disease progression.

Berner Daniel, Zenkel Matthias, Pasutto Francesca, Hoja Ursula, Liravi Panah, Gusek-Schneider Gabriele C et al.

This study found that alternative splicing and NMD regulate LOXL1 expression, adapting it to PEX-associated stresses, which may explain LOXL1's role in pseudoexfoliation glaucoma.

Schrems Wolfgang A, Schrems-Hoesl Laura-M, Mardin Christian Y, Laemmer Robert, Kruse Friedrich E, Horn Folkert K

This study found OCT RNFLT and CSLO Glaucoma Probability Score independently predict future visual field conversion in glaucoma suspects, aiding earlier intervention.

Gmeiner Jonas M D, Schrems Wolfgang A, Mardin Christian Y, Laemmer Robert, Kruse Friedrich E, Schrems-Hoesl Laura M

This study compared BMO-MRW and RNFLT for early glaucoma detection. Both showed comparable diagnostic accuracy for preperimetric and perimetric glaucoma, suggesting they are equally useful and can complement each other in diagnosis.

Schrems-Hoesl Laura M, Schrems Wolfgang A, Laemmer Robert, Horn Folkert K, Juenemann Anselm G M, Kruse Friedrich E et al.

HRT imaging (GPS/discriminant functions) predicted future visual field conversion in early glaucoma patients. Normal baseline results strongly indicated no VF loss over 10 years, aiding clinical prognosis.

Schrems Wolfgang A, Schrems-Hoesl Laura M, Mardin Christian Y, Horn Folkert K, Juenemann Anselm G M, Kruse Friedrich E et al.

Long-term glaucoma drugs, especially prostaglandins (alone or combined), can significantly decrease central corneal thickness. This necessitates regular CCT measurements to avoid underestimating intraocular pressure.

Schrems Wolfgang A, Schrems-Hoesl Laura M, Bendschneider Delia, Mardin Christian Y, Laemmer Robert, Kruse Friedrich E et al.

This study found high agreement when predicting mean retinal nerve fiber layer thickness between TD-OCT and SD-OCT using conversion equations, allowing for longitudinal comparability in glaucoma management despite potential individual sector errors.

Hoesl Laura Maria, Tornow Ralf P, Schrems Wolfgang A, Horn Folkert K, Mardin Christian Y, Kruse Friedrich E et al.

This study found that GDxVCC's glaucoma diagnostic accuracy significantly drops with atypical scan patterns, unlike SD-OCT. Clinically, SD-OCT is more reliable for glaucoma detection in eyes with unusual retinal nerve fiber layer patterns.

Tsaousis Konstantinos T, Kopsachilis Nikolaos, Tsinopoulos Ioannis T, Dimitrakos Stavros A, Kruse Friedrich E, Welge-Luessen Ulrich

This study found Trypan blue is non-toxic to human trabecular cells for exposures up to 60 seconds, but longer durations cause increasing damage. This guides safe surgical use in glaucoma.

Wessel Julia M, Horn Folkert K, Tornow Ralf P, Schmid Matthias, Mardin Christian Y, Kruse Friedrich E et al.

SD-OCT tracked RNFL thinning in glaucoma. Progressive glaucoma showed significantly faster RNFL loss than stable glaucoma or healthy eyes, highlighting its clinical utility for monitoring.

Schlötzer-Schrehardt Ursula, Hammer Christian M, Krysta Anita W, Hofmann-Rummelt Carmen, Pasutto Francesca, Sasaki Takako et al.

LOXL1 deficiency and elastic fiber disruption in the lamina cribrosa of pseudoexfoliation eyes create an elastinopathy, increasing glaucoma risk by making the optic nerve vulnerable to damage.

Braunsmann Christoph, Hammer Christian M, Rheinlaender Johannes, Kruse Friedrich E, Schäffer Tilman E, Schlötzer-Schrehardt Ursula

This study found lamina cribrosa and peripapillary sclera in pseudoexfoliation eyes were significantly softer than normal. This increased deformability may explain why PEX eyes are more vulnerable to glaucomatous damage.

Krueger Bettina, Schlötzer-Schrehardt Ursula, Haerteis Silke, Zenkel Matthias, Chankiewitz Verena E, Amann Kerstin U et al.

This study found all four ENaC subunits are widely expressed in normal human eye tissues, including cornea, ciliary body, and retina, with distinct protein localization. No ENaC mRNA changes were seen in glaucoma, suggesting potential roles in ocular fluid dynamics, but further research is needed.

Rössler Christopher W, Baleanu Delia, Reulbach Udo, Lewczuk Piotr, Bleich Stefan, Kruse Friedrich E et al.

This study found no link between elevated plasma homocysteine levels and normal tension glaucoma, suggesting homocysteine is unlikely a modifiable risk factor for NTG.

Bendschneider Delia, Tornow Ralf P, Horn Folkert K, Laemmer Robert, Roessler Christopher W, Juenemann Anselm G et al.

This study established normal SOCT RNFL values, finding thickness significantly decreases with age and axial length. This highlights the need for age-adjusted normative databases for accurate glaucoma diagnosis.

Krumbiegel Mandy, Pasutto Francesca, Mardin Christian Y, Weisschuh Nicole, Paoli Daniela, Gramer Eugen et al.

This study found no association between APOE genotypes and pseudoexfoliation syndrome or glaucoma in German and Italian populations, suggesting APOE is not a genetic risk factor for these conditions.

Kraft Michaela E, Glaeser Hartmut, Mandery Kathrin, König Jörg, Auge Daniel, Fromm Martin F et al.

This study found OATP2A1 transports latanoprost acid and is highly expressed in human ocular tissues, suggesting it's crucial for latanoprost's intraocular action and may explain variable patient responses.

Krumbiegel Mandy, Pasutto Francesca, Mardin Christian Y, Weisschuh Nicole, Paoli Daniela, Gramer Eugen et al.

This study found a CLU gene variant (rs2279590) associated with PEX syndrome in Germans, but not Italians, suggesting population-specific genetic risk for this glaucoma-related condition.

Horn Folkert K, Mardin Christian Y, Laemmer Robert, Baleanu Delia, Juenemann Anselm M, Kruse Friedrich E et al.

This study found a strong correlation between local visual field defects and peripapillary nerve fiber layer thinning in glaucoma, especially with SOCT. This highlights SOCT's utility in assessing structural-functional damage.