Sieving Paul A

Wen Rong, Tao Weng, Li Yiwen, Sieving Paul A

CNTF promotes survival of retinal photoreceptors and ganglion cells in animal models, showing promise for treating human retinal degenerative diseases.

Machida Shigeki, Raz-Prag Dorit, Fariss Robert N, Sieving Paul A, Bush Ronald A

This study found that a unique negative ERG response in RCS rats, driven by amacrine cell activity, differentiates their retinal degeneration from P23H rats, highlighting model-specific inner retinal pathology.

Brzezinski Joseph A, Brown Nadean L, Tanikawa Atsuhiro, Bush Ronald A, Sieving Paul A, Vitaterna Martha H et al.

Math5 mutant mice lacking RGCs showed no light-driven circadian entrainment and abnormal retinal electrophysiology, highlighting RGCs' critical role in photoentrainment and retinal function.

Takada Yuichiro, Fariss Robert N, Tanikawa Atsuhiro, Zeng Yong, Carper Deborah, Bush Ronald et al.

Retinoschisin expression begins in retinal ganglion cells, then spreads to other inner retinal neurons, suggesting local synthesis. This supports protein replacement therapy for X-linked retinoschisis.

Moroi Sayoko E, Lark Kurt K, Sieving Paul A, Nouri-Mahdavi Kouros, Schlötzer-Schrehardt Ursula, Katz Gregory J et al.

Long anterior zonules inserting centrally on the lens capsule cause pigment dispersion by mechanically disrupting the iris, leading to glaucoma-related signs without exfoliation material.