Grehn Franz

Abegao Pinto Luis, Sunaric Mégevand Gordana, Stalmans Ingeborg, Azuara-Blanco Augusto, Bron Alain, Garcia Feijoo Julian et al.

This EGS guide explores new glaucoma surgeries, aiming to provide evidence-based answers on their safety, efficacy, and role compared to traditional methods, to help clinicians make informed, individualized treatment decisions.

Laspas Panagiotis, Wahl Jochen, Peters Henning, Prokosch-Willing Verena, Chronopoulos Panagiotis, Grehn Franz et al.

Hoffmann Esther M, Aghayeva Fidan, Schuster Alexander K, Pfeiffer Norbert, Karsten Mona, Schweiger Susann et al.

Childhood glaucoma surgeries effectively reduced eye pressure long-term in both congenital and secondary cases, with 360° catheter-assisted trabeculotomy showing the most promising results.

Laspas Panagiotis, Wahl Jochen, Peters Henning, Prokosch-Willing Verena, Chronopoulos Panagiotis, Grehn Franz et al.

This study found that bleb revision with conjunctival grafts (alone or with scleral grafts) effectively and safely treats late-onset bleb leakage and hypotony after trabeculectomy, restoring IOP and improving vision.

Arad Tschingis, Hoffmann Esther M, Prokosch-Willing Verena, Pfeiffer Norbert, Grehn Franz

This study found XEN-augmented Baerveldt implants showed promising short-term IOP control in refractory childhood glaucoma, offering a potential new treatment, though long-term efficacy requires further study.

Toshev Anani P, Much Martin M, Klink Thomas, Pfeiffer Norbert, Hoffmann Esther M, Grehn Franz

Catheter-assisted 360-degree trabeculotomy effectively lowers intraocular pressure in most congenital glaucoma patients, particularly in previously unoperated eyes, offering a safe and viable surgical option.

Grehn Franz

Unterlauft Jan D, Elsaesser Katharina, Grehn Franz, Geerling Gerd

After DSEK, IOP trended up, but trabecular outflow facility *improved*. This suggests post-DSEK corneal rigidity changes likely affect IOP measurements, rather than true outflow impairment.

Matlach Juliane, Dhillon Christine, Hain Johannes, Schlunck Günther, Grehn Franz, Klink Thomas

This study compared trabeculectomy and canaloplasty for open-angle glaucoma, finding trabeculectomy achieved lower IOP but with more complications, suggesting canaloplasty for moderate IOP reduction and fewer risks.

Wecker Thomas, Han Hong, Börner Juliane, Grehn Franz, Schlunck Günther

TGF-β2 enhances cell-cell adhesion and β-catenin in HTM cells. This may alter TM biomechanics and Wnt signaling, contributing to glaucoma pathophysiology.

Matlach Juliane, Grehn Franz, Klink Thomas

This case links Klinefelter syndrome with goniodysgenesis and glaucoma, suggesting a rare but important ocular manifestation. Clinicians should consider this association in Klinefelter patients.

Han Hong, Wecker Thomas, Grehn Franz, Schlunck Günther

Studying human TM cells, researchers found ECM elasticity significantly modulates TGF-β2 responses, with increasing elasticity promoting protein expression patterns seen in primary open-angle glaucoma.

Grehn Franz, Klink Thomas

A new 6 o'clock corneal traction suture technique for glaucoma filtration surgery was found safe and effective, minimizing surgical site distortion and perforation risk, offering improved surgical visualization.

von Freyberg Axel, Sorg Michael, Fuhrmann Martina, Kreiner Christine F, Pfannkuche Jens, Klink Thomas et al.

This study explored acoustic tonometry in porcine eyes, finding that eye oscillation amplitude inversely correlates with IOP. This suggests a promising new non-contact method for glaucoma diagnosis and monitoring.

Schargus Marc, Grehn Franz, Glaucocard Workgroup

This project defined standardized digital glaucoma datasets, enabling improved cross-national data exchange and teleconsultation, ultimately enhancing glaucoma care quality and efficiency.

Schlunck Günther, Han Hong, Wecker Thomas, Kampik Daniel, Meyer-ter-Vehn Tobias, Grehn Franz

ECM rigidity impacts HTM cell function, protein expression, and signaling. This suggests ECM changes in glaucoma may alter outflow and contribute to the disease.

Grehn Franz, Holló Gábor, Khaw Peng, Overton Barry, Wilson Rosamund, Vogel Roger et al.

This study identified factors influencing trabeculectomy success: pigmentary glaucoma, high C/D ratio, and corneal traction sutures improved outcomes, while Black race and suture release/lysis were linked to failure.

Khaw Peng, Grehn Franz, Holló Gábor, Overton Barry, Wilson Rosamund, Vogel Roger et al.

CAT-152, an anti-scarring drug, was tested in trabeculectomy patients. It showed no benefit over placebo in preventing surgical failure, indicating it's not effective for this purpose.

Alsheikheh Ali, Klink Janine, Klink Thomas, Steffen Heimo, Grehn Franz

This study found childhood glaucoma surgery effectively lowers IOP long-term, but most children still achieve subnormal vision despite treatment, highlighting persistent visual challenges.

Guthoff Rainer, Klink Thomas, Schlunck Guenther, Grehn Franz

Confocal microscopy of trabeculectomy blebs revealed distinct stromal patterns and cellular features, some correlating with bleb function and time, offering new insights beyond slit-lamp examination.

Walland Mark J, Carassa Roberto G, Goldberg Ivan, Grehn Franz, Heuer Dale K, Khaw Peng T et al.

Experts recommend surgery (trabeculectomy) for glaucoma progression despite "normal" intraocular pressure on full medical treatment, highlighting that IOP alone isn't the sole treatment target.

Gottanka Johannes, Johnson Douglas H, Grehn Franz, Lütjen-Drecoll Elke

This study found pigmentary glaucoma involves trabecular cell loss, lamellar fusion, and extracellular material increase in the meshwork, contributing to elevated IOP. Surgical specimens may underrepresent these changes due to artifacts.

Schneider Evelin, Grehn Franz

This study compared DCT and GAT for IOP measurement, finding DCT less affected by corneal thickness but generally reading higher. DCT offers more reliable IOP for cooperative patients.

Marquardt Dirk, Lieb Wolfgang E, Grehn Franz

Intensified post-trabeculectomy care, involving active wound healing modulation, significantly increased medication-free intraocular pressure control compared to conventional follow-up. This highlights the benefit of specialized postoperative management.

Wimmer Iris, Welge-Luessen Ulrich, Picht Greda, Grehn Franz

Prior argon laser trabeculoplasty (ALT) increased activated TGF-beta 2 and bleb scarring risk in exfoliation glaucoma patients, suggesting ALT may worsen surgical outcomes in this group.