Gorgels Theo G M F

Vallbona-Garcia Antoni, Gustavsson Simon T, Gorgels Theo G M F, Tribble James R, Webers Carroll A B, Smeets Hubert J M et al.

Plasma eNAMPT levels didn't differ between glaucoma patients and controls, nor did supplementation change them. Thus, circulating eNAMPT isn't a direct glaucoma biomarker or short-term nicotinamide response indicator.

van Mechelen Ralph J S, Wolters Jarno E J, Herfs Marjolein, Bertens Christian J F, Gijbels Marion, Pinchuk Leonard et al.

Rabbit microshunt surgery showed diverse cells, beyond just myofibroblasts, contribute to wound healing and bleb failure. Targeting these varied cells could improve future glaucoma surgery outcomes.

Hubens Wouter H G, Krauskopf Julian, Beckers Henny J M, Kleinjans Jos C S, Webers Carroll A B, Gorgels Theo G M F

This study found seven microRNAs were differentially expressed in aqueous humor of POAG patients, but not plasma. These could serve as diagnostic biomarkers or therapeutic targets for glaucoma.

Wolters Jarno E J, van Mechelen Ralph J S, Al Majidi Rana, Pinchuk Leonard, Webers Carroll A B, Beckers Henny J M et al.

Mitomycin C improves glaucoma surgery success by reducing scarring, but failures persist. Future improvements may involve optimizing dose/delivery, like sustained-release systems.

Liesenborghs Ilona, Eijssen Lars M T, Kutmon Martina, Gorgels Theo G M F, Evelo Chris T, Beckers Henny J M et al.

This study identified nine molecular pathways (e.g., ECM, inflammation) in the trabecular meshwork linked to corticosteroid-induced ocular hypertension, offering targets for future treatments.

Liesenborghs Ilona, Eijssen Lars M T, Kutmon Martina, Gorgels Theo G M F, Evelo Chris T, Beckers Henny J M et al.

Analyzing TM gene expression, this study found POAG involves ECM, inflammation, complement, senescence, and Rho GTPase pathways. This confirms known mechanisms and identifies potential drug targets for glaucoma treatment.

Janssen Sarah F, Gorgels Theo G M F, Ramdas Wishal D, Klaver Caroline C W, van Duijn Cornelia M, Jansonius Nomdo M et al.

This study reviewed 65 POAG genes, finding they converge into four functional networks (development, lipid metabolism, inflammation), significantly improving glaucoma risk assessment and enabling personalized medicine.