Klaver Caroline C W

de Vries Victor A, van Garderen Karin A, Klaver Caroline C W, Bos Daniel, Kavousi Maryam, Ramdas Wishal D

Carotid atherosclerosis (cIMT) was linked to higher open-angle glaucoma risk, thinner retinal nerve fiber layer, younger diagnosis, and increased surgery, suggesting carotid screening for progressive OAG.

Vergroesen Joëlle E, Thee Eric F, Ahmadizar Fariba, van Duijn Cornelia M, Stricker Bruno H, Kavousi Maryam et al.

This study found untreated diabetes increases glaucoma, AMD, and cataract risks. Metformin was linked to lower glaucoma risk, and other diabetes drugs to lower AMD risk, suggesting potential protective effects warranting further trials.

Quint Wim H, Tadema Kirke C D, Crins Johan H C, Kokke Nina C C J, Meester-Smoor Magda A, Willemsen Rob et al.

This study developed a zebrafish screening pipeline to assess ocular health. It successfully identified disease-like changes in mutant fish, validating zebrafish as a promising model for gene screening in human eye diseases.

Nguyen Xuan-Thanh-An, Talib Mays, van Schooneveld Mary J, Wijnholds Jan, van Genderen Maria M, Schalij-Delfos Nicoline E et al.

This 2-year study of CRB1 retinal dystrophies found visual acuity and fields stable, but microperimetry showed significant retinal sensitivity decline. Microperimetry may be a sensitive clinical trial endpoint for progression.

Bonnemaijer Pieter W M, Lo Faro Valeria, Sanyiwa Anna J, Hassan Hassan G, Cook Colin, Van de Laar Suzanne et al.

This study found Sub-Saharan Africans with glaucoma present younger with more severe disease (worse vision, higher pressure, larger optic nerve damage), highlighting a more aggressive course.

Haarman Annechien E G, Enthoven Clair A, Tideman J Willem L, Tedja Milly S, Verhoeven Virginie J M, Klaver Caroline C W

This study found all myopia degrees significantly increase risks for macular degeneration, retinal detachment, cataract, and glaucoma, highlighting the need for prevention and treatment across all myopia levels.

Ghanbari Mohsen, Iglesias Adriana I, Springelkamp Henriët, van Duijn Cornelia M, Ikram M Arfan, Dehghan Abbas et al.

This study found specific genetic variants in microRNAs and their binding sites are linked to glaucoma traits, suggesting these miRNAs and their target genes are potential therapeutic targets for POAG.

Bonnemaijer Pieter W M, Cook Colin, Nag Abhishek, Hammond Christopher J, van Duijn Cornelia M, Lemij Hans G et al.

Genetic African ancestry was linked to thinner corneas and higher intraocular pressure in glaucoma patients, suggesting corneal thickness may not be a glaucoma risk factor in those with high African ancestry.

Nag Abhishek, Lu Han, Arno Matthew, Iglesias Adriana I, Bonnemaijer Pieter, Broer Linda et al.

This study found the common Gln368Stop MYOC mutation has much lower penetrance for glaucoma/high IOP than previously thought, reducing its utility as a glaucoma screening tool.

Roosing Susanne, van den Born L Ingeborgh, Sangermano Riccardo, Banfi Sandro, Koenekoop Robert K, Zonneveld-Vrieling Marijke N et al.

Mutations in the MFSD8 gene were found to cause a new form of nonsyndromic autosomal recessive macular dystrophy. This links MFSD8 to a milder eye-specific disease, expanding its clinical spectrum beyond severe neurological conditions.

Janssen Sarah F, Gorgels Theo G M F, Ramdas Wishal D, Klaver Caroline C W, van Duijn Cornelia M, Jansonius Nomdo M et al.

This study reviewed 65 POAG genes, finding they converge into four functional networks (development, lipid metabolism, inflammation), significantly improving glaucoma risk assessment and enabling personalized medicine.

Springelkamp Henriët, Lee Kyungmoo, Ramdas Wishal D, Vingerling Johannes R, Hofman Albert, Klaver Caroline C W et al.

This study found that combining macular RNFL and RGCL thickness over larger areas significantly improves 3D OCT test-retest variability, crucial for reliable glaucoma monitoring.

Thiadens Alberta A H J, Slingerland Niki W R, Florijn Ralph J, Visser Gerhard H, Riemslag Frans C, Klaver Caroline C W

This study found cone-rod dystrophy (CRD) in a Danon disease family, a novel manifestation causing progressive vision loss. This highlights the need for comprehensive eye exams in Danon patients.

Thiadens Alberta A H J, Phan T My Lan, Zekveld-Vroon Renate C, Leroy Bart P, van den Born L Ingeborgh, Hoyng Carel B et al.

This study found that both cone and cone-rod dystrophies lead to legal blindness, with cone-rod dystrophy progressing faster. ABCA4 mutations and early onset predict worse visual outcomes.

van Koolwijk Leonieke M E, Despriet Dominiek D G, Van Duijn Cornelia M, Oostra Ben A, van Swieten John C, de Koning Inge et al.

This study found better cognitive function is linked to thicker retinal nerve fiber layers, especially in younger individuals, suggesting shared neural health but potentially distinct age-related neurodegeneration.

van Koolwijk Leonieke M E, Despriet Dominiek D G, van Duijn Cornelia M, Pardo Cortes Luba M, Vingerling Johannes R, Aulchenko Yurii S et al.

This study found that intraocular pressure, RNFL thickness, and optic disc parameters, key glaucoma markers, are strongly inherited, supporting genetic research to identify new glaucoma genes.