Harris A

Siaudvytyte L, Januleviciene I, Daveckaite A, Ragauskas A, Bartusis L, Kucinoviene J et al.

This review found translaminar pressure difference (TPD) is higher in open-angle glaucoma patients and linked to optic nerve damage, suggesting its importance in disease understanding and future research.

Costa V P, Arcieri E S, Harris A

This review highlights that ocular perfusion pressure, derived from blood pressure and IOP, is a crucial vascular factor in glaucoma progression, even with controlled IOP.

Traustason S, Hardarson S H, Gottfredsdottir M S, Eysteinsson T, Karlsson R A, Stefánsson E et al.

This study found that switching from dorzolamide-timolol combination to timolol alone lowered retinal vessel oxygen saturation, suggesting the combination may improve retinal oxygen delivery in glaucoma/ocular hypertension.

Plange N, Kaup M, Weber A, Harris A, Arend K O, Remky A

This study found color Doppler imaging detected reduced ocular blood flow in normal tension glaucoma, but its diagnostic sensitivity for distinguishing NTG from healthy eyes was limited to 48%.

Siesky B, Harris A, Cantor L B, Kagemann L, Weitzman Y, McCranor L et al.

This study found that both brinzolamide and dorzolamide increased retinal oxygen saturation and microcirculation in glaucoma patients, potentially offering neuroprotective benefits beyond just lowering eye pressure.

Hosking S L, Harris A, Chung H S, Jonescu-Cuypers C P, Kagemann L, Roff Hilton E J et al.

This study found glaucoma patients exhibit relative ocular vasoconstriction, partially reversed by increased CO2. This suggests compromised blood flow regulation in glaucoma.

Harris A, Ishii Y, Chung H S, Jonescu-Cuypers C P, McCranor L J, Kagemann L et al.

This study found the inferior retina has lower blood flow per nerve tissue volume, suggesting it's more vulnerable to glaucoma damage from elevated IOP or ischemia.

Arend O, Remky A, Plange N, Martin B J, Harris A

This study found prolonged retinal blood transit (AVP) in normal pressure glaucoma, but this slowing isn't due to capillary loss or altered peripapillary vessel diameters, suggesting other mechanisms impact ocular circulation.

Harris A, Jonescu-Cuypers C P, Kagemann L, Nowacki E A, Garzozi H, Cole C et al.

Cosopt (dorzolamide-timolol) in glaucoma significantly lowered eye pressure and improved retinal blood flow speed compared to timolol alone, suggesting enhanced therapeutic benefits beyond pressure reduction.

Harris A, Jonescu-Cuypers C P

This review found glaucoma medications can significantly alter ocular blood flow in humans, highlighting the need to consider these vascular effects in treatment.

Leiba H, Rachmiel R, Harris A, Kagemann L, Pollack A, Zalish M

This study found optic nerve head blood flow is significantly reduced in NAION eyes and even in unaffected fellow eyes, suggesting decreased flow indicates a "disc at risk" for NAION.

Kondo Y, Niwa Y, Yamamoto T, Sawada A, Harris A, Kitazawa Y

This study found that in normal-tension glaucoma, worse visual fields were linked to significantly altered retrobulbar blood flow, particularly in the ophthalmic artery, even when ocular perfusion pressure was better.

Arend O, Remky A, Cantor L B, Harris A

This study found normal pressure glaucoma patients with asymmetric visual field loss also have asymmetric, prolonged retinal circulation times, suggesting circulatory deficits contribute significantly to glaucoma progression.

Niwa Y, Yamamoto T, Harris A, Kagemann L, Kawakami H, Kitazawa Y

Both CO2 inhalation and nilvadipine improved orbital blood flow in normal-tension glaucoma patients, suggesting CO2 response might predict nilvadipine's benefit in reducing vascular resistance.

Harris A, Ciulla T A, Kagemann L, Zarfati D, Martin B

Harris A, Arend O, Chung H S, Kagemann L, Cantor L, Martin B

In normal-tension glaucoma, dorzolamide, unlike betaxolol, improved inferotemporal retinal blood flow despite both lowering IOP. This suggests dorzolamide may offer additional neuroprotection beyond pressure reduction.

Garzozi H J, Muallem M S, Harris A

Ointment entering the anterior chamber after radial keratotomy caused recurrent uveitis and glaucoma, treatable with drops. This highlights a rare but treatable complication of corneal surgery.

Arend O, Harris A, Martin B J, Remky A

This study measured optic nerve head blood flow, finding epipapillary velocities were significantly higher than macular velocities and uncorrelated, suggesting distinct microvascular dynamics relevant to glaucoma.

Harris A, Chung H S, Ciulla T A, Kagemann L

New technologies for measuring ocular blood flow reveal deficits in glaucoma and AMD, highlighting OBF's critical role in understanding and potentially managing these blinding diseases.

Evans D W, Harris A, Garrett M, Chung H S, Kagemann L

Glaucoma patients exhibit impaired central retinal artery blood flow regulation during posture changes, unlike healthy individuals. This suggests faulty ocular autoregulation may contribute to glaucoma pathology.

Harris A, Garzozi H J, Chung H S

Chung H S, Harris A, Evans D W, Kagemann L, Garzozi H J, Martin B

Glaucoma involves vascular deficits, potentially linked to IOP and impaired autoregulation, impacting optic nerve health. Improving ocular blood flow may offer a therapeutic strategy.

Martin B, Harris A, Hammel T, Malinovsky V

Exercise-induced IOP reduction correlates strongly with changes in plasma colloid osmotic pressure (COP), not other hydration markers. This suggests COP is a key mechanism for exercise's beneficial eye pressure effect.

Brucculeri M, Hammel T, Harris A, Malinovsky V, Martin B

Water drinking elevated IOP, but not via osmotic gradients or active ion pumping. This suggests aqueous drainage factors are responsible for the transient IOP increase, which is relevant for glaucoma management.

Chung H S, Harris A, Kagemann L, Martin B

This study found normal tension glaucoma patients have significantly reduced peripapillary retinal blood flow, suggesting vascular deficits contribute to disease development and progression.