Hauser Michael A

Hauser Michael A, Allingham R Rand, Aung Tin, Van Der Heide Carly J, Taylor Kent D, Rotter Jerome I et al.

This GWAS in African ancestry populations found a specific genetic variant (APBB2) strongly linked to primary open-angle glaucoma, suggesting ancestry-specific risk assessment and therapeutic targets.

Khawaja Anthony P, Chan Michelle P Y, Yip Jennifer L Y, Broadway David C, Garway-Heath David F, Viswanathan Ananth C et al.

A study found the glaucoma-risk gene variant SIX6 rs33912345 is linked to thinner RNFL, smaller rim area, and larger cup-to-disc ratio in Europeans, showing its functional impact on optic nerve health.

Johnson William M, Finnegan Laura K, Hauser Michael A, Stamer W Daniel

This review proposes studying lncRNAs and DNA methylation in exfoliation glaucoma (XFG) to uncover novel disease pathways, potentially explaining complex genetics and leading to new therapeutic targets for this aggressive blindness.

Drewry Michelle, Helwa Inas, Allingham R Rand, Hauser Michael A, Liu Yutao

This study profiled miRNAs in normal human ciliary body, cornea, and trabecular meshwork, identifying 378 miRNAs, including novel and tissue-specific ones. This foundational data aids understanding glaucoma and keratoconus pathology.

Cai Jingwen, Perkumas Kristin M, Qin Xuejun, Hauser Michael A, Stamer W Daniel, Liu Yutao

Studying Schlemm's canal cells, researchers found glaucoma alters gene expression linked to cell adhesion and ECM remodeling, suggesting new targets for outflow resistance in glaucoma.

Wiggs Janey L, Hauser Michael A, Abdrabou Wael, Allingham Robert Rand, Budenz Donald L, Delbono Elizabeth et al.

The NEIGHBOR consortium was formed to standardize primary open-angle glaucoma (POAG) definitions for a large-scale genetic study, aiming to identify genes for improved diagnosis and treatment.

Liu Yutao, Hauser Michael A, Akafo Stephen K, Qin Xuejun, Miura Shiroh, Gibson Jason R et al.

Studying POAG genetics in African Americans and Ghanaians, researchers found Caucasian-associated risk factors play a reduced role, underscoring the need for new genetic studies in these high-risk populations.

Liu Yutao, Allingham R Rand, Qin Xuejun, Layfield David, Dellinger Andrew E, Gibson Jason et al.

This study found 483 differentially expressed genes, including exosome components, in POAG trabecular meshwork, suggesting endocytic and exosome pathways are key to glaucoma development.

Hauser Michael A, Sena Dayse Figueiredo, Flor Jason, Walter Jeff, Auguste Josette, Larocque-Abramson Karen et al.

This study found rare OPTN gene variations, like E50K, are associated with severe, familial low-tension glaucoma, suggesting genetic testing might guide therapy for at-risk patients.

Hauser Michael A, Allingham R Rand, Linkroum Kevin, Wang Jun, LaRocque-Abramson Karen, Figueiredo Dayse et al.

WDR36 gene variants were studied in POAG patients, finding they're more common in severe cases. This suggests WDR36 modifies glaucoma severity, rather than solely causing it.