Perkumas Kristin M

Stamer W Daniel, Perkumas Kristin M, Kang Min H, Dibas Mohammed, Robinson Michael R, Rhee Douglas J

This study found high-concentration bimatoprost, like that from implants, dramatically upregulates MMPs in outflow tissues, potentially explaining sustained IOP lowering and outflow remodeling, even after drug clearance.

Li Haiyan, Singh Ayushi, Perkumas Kristin M, Stamer W Daniel, Ganapathy Preethi S, Herberg Samuel

This study found that glaucoma-linked TGFβ2 activates YAP/TAZ in Schlemm's canal cells, causing dysfunction. Inhibiting YAP/TAZ improved cell function, suggesting a new therapeutic target for glaucoma.

Jasien Jessica V, Read A Thomas, van Batenburg-Sherwood Joseph, Perkumas Kristin M, Ethier C Ross, Stamer W Daniel et al.

Tree shrew anterior segment anatomy and outflow facility closely resemble humans, featuring a Schlemm's canal and trabecular meshwork. This makes them a promising, cost-effective glaucoma model, especially for anterior segment and pharmacology research.

Cai Jingwen, Perkumas Kristin M, Qin Xuejun, Hauser Michael A, Stamer W Daniel, Liu Yutao

Studying Schlemm's canal cells, researchers found glaucoma alters gene expression linked to cell adhesion and ECM remodeling, suggesting new targets for outflow resistance in glaucoma.

Rogers Morgan E, Navarro Iris D, Perkumas Kristin M, Niere Shannon M, Allingham R Rand, Crosson Craig E et al.

This study found that pigment epithelium-derived factor (PEDF) increases Schlemm's canal barrier function and significantly decreases outflow facility in mouse eyes. This suggests PEDF modulation could treat glaucoma or ocular hypotony.

Hoffman Emely A, Perkumas Kristin M, Highstrom Lindsey M, Stamer W Daniel

This study found that human trabecular meshwork cells regulate the release of myocilin-associated exosomes in response to dexamethasone, calcium, and aqueous humor, suggesting environmental cues impact this glaucoma-related process.