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Pigment epithelium-derived factor decreases outflow facility.
Rogers Morgan E, Navarro Iris D, Perkumas Kristin M, Niere Shannon M, Allingham R Rand, Crosson Craig E et al.
Invest Ophthalmol Vis SciOct 201321 citationsBasic Science
This study found that pigment epithelium-derived factor (PEDF) increases Schlemm's canal barrier function and significantly decreases outflow facility in mouse eyes. This suggests PEDF modulation could treat glaucoma or ocular hypotony.