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38 articles in GJC
Rhee Douglas J, Sancheti Himani, Rothman Adam L, Herndon Leon, Brubaker Jacob W, Patrianakos Thomas et al.
A survey of ophthalmologists found most use drops for initial POAG treatment, but about 25% prefer laser, especially US doctors, newer practitioners, and those with a larger glaucoma patient base. This highlights evolving practice patterns.
Stamer W Daniel, Perkumas Kristin M, Kang Min H, Dibas Mohammed, Robinson Michael R, Rhee Douglas J
This study found high-concentration bimatoprost, like that from implants, dramatically upregulates MMPs in outflow tissues, potentially explaining sustained IOP lowering and outflow remodeling, even after drug clearance.
Saini Chhavi, Chen Teresa C, Young Lucy H, Vavvas Demetrios G, Vangel Mark, Papaliodis George N et al.
BK2 implantation significantly improved vision in severe cicatricial OSD patients, but glaucoma and other complications were common. It's a viable option, especially with concurrent glaucoma management.
Kalarn Sachin, Le Tinh, Rhee Douglas J
This review found MIGS combined with cataract surgery benefits glaucoma patients, potentially delaying incisional surgery, though trabeculectomy with MMC remains optimal for specific severe cases.
Ahmed Iqbal Ike K, Rhee Douglas J, Jones Jason, Singh Inder Paul, Radcliffe Nathan, Gazzard Gus et al.
The HORIZON study found Hydrus Microstent combined with cataract surgery safely reduced glaucoma medications and future surgery more effectively than cataract surgery alone for mild-to-moderate POAG.
Ashok Ajay, Chaudhary Suman, Kritikos Alexander E, Kang Min H, McDonald Dallas, Rhee Douglas J et al.
TGF-β2 upregulates hepcidin in the TM, creating an iron-mediated, self-sustaining loop that drives glaucoma pathology. Targeting this loop with hepcidin antagonists or antioxidants may offer new POAG treatments.
Lin Michael M, Rageh Abdulrahman, Turalba Angela V, Lee Hang, Falkenstein Iryna A, Hoguet Ambika S et al.
Combined phaco/ECP surgery reduced eye pressure more in angle-closure glaucoma than open-angle, benefiting all glaucoma stages. This suggests better outcomes for angle-closure patients.
Ahmed Iqbal Ike K, Fea Antonio, Au Leon, Ang Robert E, Harasymowycz Paul, Jampel Henry D et al.
This study compared standalone Hydrus vs. iStent MIGS for open-angle glaucoma. Hydrus showed higher surgical success and greater medication reduction, suggesting it may be a more effective option.
Rabin Richard L, Rabin Arnold R, Zhang Amy D, Burney Edward N, Rhee Douglas J
This review discusses co-managing cataract and glaucoma with phacoemulsification and various IOP-lowering options, highlighting recent evidence for new MIGS devices. This helps ophthalmologists plan optimal surgical strategies.
Töteberg-Harms Marc, Rhee Douglas J
This study found SLT after failed phaco-trabectome surgery had limited, short-term IOP-lowering effect. Clinically, other interventions like incisional surgery should be considered instead.
Keller Kate E, Vranka Janice A, Haddadin Ramez I, Kang Min-Hyung, Oh Dong-Jin, Rhee Douglas J et al.
Studying Tenascin C (TNC) in the eye's drain, researchers found that reducing TNC did not impact fluid outflow resistance or intraocular pressure, suggesting it doesn't directly cause glaucoma.
Oh Dong-Jin, Kang Min Hyung, Ooi Yen Hoong, Choi Kyu Ryong, Sage E Helene, Rhee Douglas J
SPARC overexpression in human trabecular meshwork increased intraocular pressure by altering extracellular matrix composition and turnover. This suggests SPARC is a potential glaucoma therapeutic target.
Kang Min Hyung, Oh Dong-Jin, Kang Ja-heon, Rhee Douglas J
This study found that elevated TGF-β2, linked to glaucoma, increases SPARC protein in human trabecular meshwork. This suggests SPARC could be a target for new glaucoma therapies.
Swaminathan Swarup S, Oh Dong-Jin, Kang Min Hyung, Ren Ruiyi, Jin Rui, Gong Haiyan et al.
SPARC-null mice showed more uniform aqueous outflow and lower IOP due to altered trabecular meshwork collagen. This suggests SPARC modulates outflow, offering a potential target for glaucoma therapy.
Haddadin Ramez I, Oh Dong-Jin, Kang Min Hyung, Villarreal Guadalupe, Kang Ja-Heon, Jin Rui et al.
Studying TSP1/TSP2-null mice, researchers found these proteins regulate IOP. Their absence led to lower IOP, suggesting TSP1/TSP2 inhibition could be a novel glaucoma treatment target.
Tanna Angelo P, Budenz Donald L, Bandi Jagadeesh, Feuer William J, Feldman Robert M, Herndon Leon W et al.
This study compared GPA software with expert consensus for detecting glaucoma visual field progression. It found fair agreement, with experts more often identifying progression than the software, highlighting the value of clinical judgment.
Jea Seung Youn, Mosaed Sameh, Vold Steven D, Rhee Douglas J
This study found that a failed trabectome procedure does not negatively affect the success rate or complication profile of a subsequent trabeculectomy, suggesting it's a safe initial surgical option.
Jea Seung Youn, Francis Brian A, Vakili Ghazal, Filippopoulos Theodoros, Rhee Douglas J
This study compared ab interno trabeculectomy with traditional trabeculectomy for open-angle glaucoma. Trabeculectomy achieved significantly better IOP reduction and success rates, but with more complications, indicating it remains the more effective surgery.
Chowdhury Uttio Roy, Jea Seung-Youn, Oh Dong-Jin, Rhee Douglas J, Fautsch Michael P
This study found osteopontin (OPN) levels are lower in POAG aqueous humor. This suggests OPN may play a role in glaucoma pathogenesis, potentially as a biomarker or therapeutic target, though its direct impact on IOP needs further investigation.
Villarreal Guadalupe, Oh Dong-Jin, Kang Min Hyung, Rhee Douglas J
The miR-29 family critically suppresses ECM in the trabecular meshwork. Its TGF-β2-mediated modulation offers a potential therapeutic target for glaucoma, influencing outflow resistance.
Jackson Mary Lou, Drohan Brian, Agrawal Khushboo, Rhee Douglas J
Kang Min Hyung, Oh Dong-Jin, Rhee Douglas J
Hevin, expressed in the trabecular meshwork, was studied in mice. Unlike its relative SPARC, hevin deletion did not affect IOP, suggesting it's not critical for IOP regulation in glaucoma.
Tanna Angelo P, Bandi Jagadeesh R, Budenz Donald L, Feuer William J, Feldman Robert M, Herndon Leon W et al.
Glaucoma experts showed good intraobserver visual field progression reproducibility, but only moderate interobserver agreement, which GPA data did not improve, highlighting subjective interpretation challenges.