Chowdhury Uttio Roy

Roddy Gavin W, Kohli Darrell, Niknam Parvin, Omer Mohammed E, Chowdhury Uttio Roy, Anderson Kjersten J et al.

Subconjunctival gene therapy (AAV-STC-1) significantly lowered intraocular pressure in mice for weeks, offering a potential sustained glaucoma treatment with fewer side effects than daily drops.

Chowdhury Uttio Roy, Holman Bradley H, Fautsch Michael P

K(ATP) channel openers diazoxide and nicorandil significantly lowered intraocular pressure in mice by targeting K(ir)6.2. This suggests a novel therapeutic pathway for glaucoma management.

Chowdhury Uttio Roy, Jea Seung-Youn, Oh Dong-Jin, Rhee Douglas J, Fautsch Michael P

This study found osteopontin (OPN) levels are lower in POAG aqueous humor. This suggests OPN may play a role in glaucoma pathogenesis, potentially as a biomarker or therapeutic target, though its direct impact on IOP needs further investigation.

Chowdhury Uttio Roy, Bahler Cindy K, Hann Cheryl R, Chang Minhwang, Resch Zachary T, Romero Michael F et al.

Activating K(ATP) channels in the eye's drainage system increases fluid outflow and lowers intraocular pressure, suggesting a new therapeutic target for glaucoma treatment.

Howell Kyle G, Vrabel Anne M, Chowdhury Uttio Roy, Stamer William Daniel, Fautsch Michael P

This study found myocilin levels are significantly elevated in primary open-angle glaucoma aqueous humor, but not in pseudoexfoliation glaucoma, suggesting a specific biomarker for POAG.

Chowdhury Uttio Roy, Madden Benjamin J, Charlesworth Mary Christine, Fautsch Michael P

This study identified 676 proteins in human aqueous humor, with over 80% being novel. This comprehensive proteome map provides a foundation for discovering disease biomarkers in anterior segment conditions like glaucoma.