Ooi Yen Hoong

2 articles in GJC

Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix.

Oh Dong-Jin, Kang Min Hyung, Ooi Yen Hoong, Choi Kyu Ryong, Sage E Helene, Rhee Douglas J

Invest Ophthalmol Vis SciMay 201349 citationsBasic Science

SPARC overexpression in human trabecular meshwork increased intraocular pressure by altering extracellular matrix composition and turnover. This suggests SPARC is a potential glaucoma therapeutic target.

Full abstract PubMed

Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells.

Ooi Yen Hoong, Oh Dong-Jin, Rhee Douglas J

Invest Ophthalmol Vis SciNov 200934 citationsBasic Science

This study found that glaucoma eye drops (PGAs) differentially alter MMPs and TIMPs in ciliary body cells, with unoprostone uniquely decreasing MMP-2 and increasing TIMP-1/4, explaining its lower clinical efficacy.

Full abstract PubMed

All 2 articles loaded

Global Search

Ooi Yen Hoong

Overexpression of SPARC in human trabecular meshwork increases intraocular pressure and alters extracellular matrix.

Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells.