1.
Secreted protein acidic and rich in cysteine (SPARC)-null mice exhibit more uniform outflow.
Swaminathan Swarup S, Oh Dong-Jin, Kang Min Hyung, Ren Ruiyi, Jin Rui, Gong Haiyan et al.
Invest Ophthalmol Vis SciMar 201380 citationsBasic Science
SPARC-null mice showed more uniform aqueous outflow and lower IOP due to altered trabecular meshwork collagen. This suggests SPARC modulates outflow, offering a potential target for glaucoma therapy.