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TGFฮฒ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology.
Ashok Ajay, Chaudhary Suman, Kritikos Alexander E, Kang Min H, McDonald Dallas, Rhee Douglas J et al.
Invest Ophthalmol Vis SciMar 202014 citationsBasic Science
TGF-ฮฒ2 upregulates hepcidin in the TM, creating an iron-mediated, self-sustaining loop that drives glaucoma pathology. Targeting this loop with hepcidin antagonists or antioxidants may offer new POAG treatments.