Hisatomi Toshio

Hisatomi Toshio, Tachibana Takashi, Notomi Shoji, Nakatake Shunji, Fujiwara Kohta, Murakami Yusuke et al.

Monkey studies showed that after ILM peeling, the retina remains incompletely repaired for years, with exposed nerve fibers and structural changes resembling clinical dissociated optic nerve layer or dimple signs.

Fujiwara Kohta, Ikeda Yasuhiro, Murakami Yusuke, Nakatake Shunji, Tachibana Takashi, Yoshida Noriko et al.

This study found elevated intraocular inflammation (aqueous flare) is associated with epiretinal membrane in retinitis pigmentosa, suggesting inflammation may cause this complication.

Yoshida Noriko, Ikeda Yasuhiro, Murakami Yusuke, Nakatake Shunji, Fujiwara Kota, Notomi Shoji et al.

This study found cataract surgery improved vision in about half of RP patients. Preoperative visual field (MD) and OCT ellipsoid zone status predict postoperative visual outcomes, guiding patient selection.

Yoshida Noriko, Ikeda Yasuhiro, Notomi Shoji, Ishikawa Keijiro, Murakami Yusuke, Hisatomi Toshio et al.

This study found sustained inflammation (vitreous cells, elevated cytokines) in retinitis pigmentosa patients. This suggests inflammation contributes to RP progression, opening avenues for anti-inflammatory treatments.

Ikeda Yasuhiro, Hisatomi Toshio, Yoshida Noriko, Notomi Shoji, Murakami Yusuke, Enaida Hiroshi et al.

Topical dorzolamide effectively reduced retinal thickness and improved macular sensitivity in patients with retinitis pigmentosa-associated cystoid macular edema, offering a promising treatment for this vision-threatening complication.

Yoshida Noriko, Hisatomi Toshio, Ikeda Yasuhiro, Kohno Ri-ichiro, Murakami Yusuke, Imaki Hiroyuki et al.

Intravitreal bevacizumab for neovascular glaucoma reduced inflammation, edema, and vascular congestion, plus caused endothelial cell degeneration in trabeculectomy specimens, suggesting its beneficial biological effects.

Kohno Ri-ichiro, Hata Yasuaki, Mochizuki Yasutaka, Arita Ryoichi, Kawahara Shuhei, Kita Takeshi et al.

Intravitreal bevacizumab in PDR/NVG eyes caused endothelial cell death and vessel normalization (reduced fenestrations, increased pericytes). This suggests bevacizumab helps regress and stabilize abnormal new vessels.

Kubota Toshiaki, Okabe Hakuoh, Hisatomi Toshio, Yamakiri Keita, Sakamoto Taiji, Tawara Akihiko

This study found intravitreal triamcinolone can cause TM changes, including extracellular matrix deposition, resembling topical steroid glaucoma, highlighting a mechanism for IOP elevation.

Enaida Hiroshi, Hata Yasuaki, Ueno Akifumi, Nakamura Takao, Hisatomi Toshio, Miyazaki Miho et al.

TA-assisted vitrectomy may reduce reoperations for preretinal fibrosis without serious complications, suggesting its potential benefit in retinal surgery.

Sakamoto Taiji, Miyazaki Miho, Hisatomi Toshio, Nakamura Takao, Ueno Akifumi, Itaya Keiko et al.

Triamcinolone during vitrectomy improved hyaloid visibility, aiding safer surgery, and significantly reduced postoperative blood-ocular barrier breakdown in proliferative retinal diseases, suggesting improved outcomes.